Inflammation in epileptogenesis after traumatic brain injury

KM Webster, M Sun, P Crack, TJ O'Brien… - Journal of …, 2017 - Springer
Background Epilepsy is a common and debilitating consequence of traumatic brain injury
(TBI). Seizures contribute to progressive neurodegeneration and poor functional and …

Neuroinflammatory mechanisms of post-traumatic epilepsy

S Mukherjee, GM Arisi, K Mims, G Hollingsworth… - Journal of …, 2020 - Springer
Background Traumatic brain injury (TBI) occurs in as many as 64–74 million people
worldwide each year and often results in one or more post-traumatic syndromes, including …

Neuroinflammation in post-traumatic epilepsy: pathophysiology and tractable therapeutic targets

R Sharma, WL Leung, A Zamani, TJ O'brien… - Brain sciences, 2019 - mdpi.com
Epilepsy is a common chronic consequence of traumatic brain injury (TBI), contributing to
increased morbidity and mortality for survivors. As post-traumatic epilepsy (PTE) is drug …

Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury

CL Eastman, R D'Ambrosio, T Ganesh - Neuropharmacology, 2020 - Elsevier
Traumatic brain injury (TBI) is a leading cause of death and disability in young adults
worldwide. TBI survival is associated with persistent neuropsychiatric and neurological …

The role of inflammation in epileptogenesis

A Vezzani, A Friedman, RJ Dingledine - Neuropharmacology, 2013 - Elsevier
One compelling challenge in the therapy of epilepsy is to develop anti-epileptogenic drugs
with an impact on the disease progression. The search for novel targets has focused …

Behavioral comorbidities of epilepsy and neuroinflammation: Evidence from experimental and clinical studies

EM Suleymanova - Epilepsy & Behavior, 2021 - Elsevier
Currently, a significant amount of data is accumulated showing that neuroinflammation is
one of the key processes in the development of brain pathology in trauma …

Neuroinflammatory mediators in acquired epilepsy: an update

Y Chen, MM Nagib, N Yasmen, MN Sluter… - Inflammation …, 2023 - Springer
Epilepsy is a group of chronic neurological disorders that have diverse etiologies but are
commonly characterized by spontaneous seizures and behavioral comorbidities. Although …

Neuroinflammation in epileptogenesis: from pathophysiology to therapeutic strategies

W Li, J Wu, Y Zeng, W Zheng - Frontiers in Immunology, 2023 - frontiersin.org
Epilepsy is a group of enduring neurological disorder characterized by spontaneous and
recurrent seizures with heterogeneous etiology, clinical expression, severity, and prognosis …

Inflammation and prevention of epileptogenesis

T Ravizza, S Balosso, A Vezzani - Neuroscience letters, 2011 - Elsevier
CNS injuries such as trauma, stroke, viral infection, febrile seizures, status epilepticus
occurring either in infancy or during a lifetime are considered common risk factors for …

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

P Klein, R Dingledine, E Aronica, C Bernard… - …, 2018 - Wiley Online Library
The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …