Prolyl oligopeptidase (POP), also called prolyl endopeptidase, is a cytosolic enzyme
investigated by several research groups. It has been proposed to play an important role in …

Introduction: Prolyl Oligopeptidase (POP) is a serine peptidase that cleaves post-proline
bonds in short peptides. Besides the direct hydrolytic regulation function over peptides …

The activity and lifetime of proteins or peptides in living organisms are highly dependent on
their processing by proteolytic enzymes also known as proteases. Proteases perform …

Prolyl oligopeptidase (POP) is a serine peptidase which digests small peptide-like
hormones, neuroactive peptides, and various cellular factors. Therefore, this peptidase has …

Prolyl oligopeptidase (POP) is a serine endopeptidase that hydrolyses proline-containing
peptides shorter than 30 amino acids. POP may be associated with cognitive functions …

Prolyl oligopeptidase (POP) is a ubiquitous post-proline cleaving enzyme that is highly
expressed in brain. Current knowledge about the biochemical features of POP and the …

Despite the fact that some have passed early phases of clinical trials, no prolyl
oligopeptidase inhibitors are currently on the market. Yet, since 2003, there has been a …

Background: This research aims to discover novel derivatives having potential therapeutic
applications in treating conditions related to prolyl oligopeptidase (POP) dysfunction …

Prolyl oligopeptidase (PO, EC 3.4. 21.26) is a post-proline cleaving enzyme with
endopeptidase activity towards peptides not longer than 30 amino acids. It has been purified …

Inhibitors of prolyl oligopeptidase have been reported to be neuroprotective, especially in
memory loss caused by lesion or disease. This enzyme has also been implicated in …