Mesenchymal stem cells-derived exosomes as a promising new approach for the treatment of infertility caused by polycystic ovary syndrome

M Izadi, ME Rezvani, A Aliabadi, M Karimi… - Frontiers in …, 2022 - frontiersin.org
Polycystic ovary syndrome (PCOS) is a multifactorial metabolic and most common endocrine
disorder that its prevalence, depending on different methods of evaluating PCOS traits …

Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles to treat PCOS

HS Park, E Cetin, H Siblini, J Seok, H Alkelani… - International Journal of …, 2023 - mdpi.com
Polycystic ovary syndrome (PCOS) is known as the most common endocrine disorder in
women. Previously, we suggested that human mesenchymal stem cells (MSCs) can reverse …

Human pluripotent stem cell–mesenchymal stem cell-derived exosomes promote ovarian granulosa cell proliferation and attenuate cell apoptosis induced by …

L Zhang, Y Ma, X Xie, C Du, Y Zhang, S Qin, J Xu… - Molecules, 2023 - mdpi.com
Premature ovarian insufficiency (POI) is a complex disease which causes amenorrhea,
hypergonadotropism and infertility in patients no more than 40 years old. Recently, several …

Stem cells and exosomes: as biological agents in the diagnosis and treatment of polycystic ovary syndrome (PCOS)

M Hadidi, K Karimabadi, E Ghanbari… - Frontiers in …, 2023 - frontiersin.org
A typical condition of the female reproductive system is polycystic ovary syndrome (PCOS).
Hyperinsulinemia, insulin resistance, obesity, and hyperandrogenism are just a few of the …

Stem cell-derived extracellular vesicles: A novel and potential remedy for primary ovarian insufficiency

Z Geng, H Guo, Y Li, Y Liu, Y Zhao - Frontiers in Cell and …, 2023 - frontiersin.org
Primary ovarian insufficiency (POI) is an essential cause of young female fertility loss. At
present, there are many treatments for primary ovarian insufficiency, but due to the …

Human umbilical cord mesenchymal stem cell-derived exosomes inhibit ovarian granulosa cells inflammatory response through inhibition of NF-κB signaling in …

Y Zhao, S Pan, X Wu - Journal of Reproductive Immunology, 2022 - Elsevier
Polycystic ovary syndrome (PCOS) is a common endocrine disorder and the leading cause
of anovulatory infertility in women of reproductive age. Chronic low-grade inflammation is …

Comparison of the therapeutic effects between stem cells and exosomes in primary ovarian insufficiency: as promising as cells but different persistency and dosage

H Park, RM Chugh, J Seok, E Cetin… - Stem cell research & …, 2023 - Springer
Background Primary ovarian insufficiency (POI) refers to the loss of ovarian function under
the age of 40 and results in amenorrhea and infertility. Our previous studies have shown that …

Therapeutic role of mesenchymal stem cell-derived extracellular vesicles in female reproductive diseases

Z Liao, C Liu, L Wang, C Sui, H Zhang - Frontiers in endocrinology, 2021 - frontiersin.org
Reproductive disorders, including intrauterine adhesion (IUA), premature ovarian
insufficiency (POI), and polycystic ovary syndrome (PCOS), are great threats to female …

Mesenchymal Stem-Cell Derived Exosome Therapy as a Potential Future Approach for Treatment of Male Infertility Caused by Chlamydia Infection

M Izadi, L Dehghan Marvast, ME Rezvani… - Frontiers in …, 2022 - frontiersin.org
Some microbial sexually transmitted infections (STIs) have adverse effects on the
reproductive tract, sperm function, and male fertility. Given that STIs are often asymptomatic …

Mesenchymal stem cells derived exosomal miR-323-3p promotes proliferation and inhibits apoptosis of cumulus cells in polycystic ovary syndrome (PCOS)

Y Zhao, M Tao, M Wei, S Du, H Wang… - Artificial cells …, 2019 - Taylor & Francis
Polycystic ovary syndrome (PCOS) is a heterogeneous reproductive disease. Adipose
mesenchymal stem cells (AMSCs) can produce a mass of exosomes. The objective of this …