Despite the importance of the cerebrovasculature in maintaining normal brain physiology
and in understanding neurodegeneration and drug delivery to the central nervous system …

Cerebrovascular disease is the third most common cause of death in developed countries,
but our understanding of the cells that compose the cerebral vasculature is limited. Here …

The human brain vasculature is of great medical importance: its dysfunction causes
disability and death, and the specialized structure it forms—the blood–brain barrier …

Cerebrovascular diseases are a leading cause of death and neurologic disability. Further
understanding of disease mechanisms and therapeutic strategies requires a deeper …

The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …

The cerebrovasculature is essential to brain health and is tasked with ensuring adequate
delivery of oxygen and metabolic precursors to ensure normal neurologic function. This is …

The vasculature is increasingly recognized to impact brain function in health and disease
across the life span. During embryonic brain development, angiogenesis and neurogenesis …

The blood-brain barrier (BBB) limits the entry of leukocytes and potentially harmful
substances from the circulation into the central nervous system (CNS). While BBB defects …

An important concept that has not been sufficiently represented in research into
neurodegenerative diseases1–7 is the role of the neurovascular unit. The neurovascular …

The function of the mammalian brain relies upon the specification and spatial positioning of
diversely specialized cell types. Yet, the molecular identities of the cell types and their …