Tramadol and tapentadol are fully synthetic and extensively used analgesic opioids,
presenting enhanced therapeutic and safety profiles as compared with their peers. However …

Tramadol and tapentadol are two atypical synthetic opioid analgesics, with monoamine
reuptake inhibition properties. Mainly aimed at the treatment of moderate to severe pain …

Tramadol and tapentadol, two structurally related synthetic opioid analgesics, are widely
prescribed due to the enhanced therapeutic profiles resulting from the synergistic …

Tramadol and tapentadol are extensively prescribed for the treatment of moderate to severe
pain. Although these drugs are very effective in pain treatment, the number of intoxications …

Background: Tramadol''a synthetic analgesic of opioids''is serotonin reuptake blocker. Also it
is inhibitor of norepinephrine transporter function. Objectives: to evaluate the effect of …

The present study was designed to investigate the effects of different doses of tramadol
hydrochloride (TH) on histopathological and biochemical changes in male rabbits. Fifteen …

The purpose of this study was to evaluate the possible neurodegeneration and oxidative
stress induced bytramadol administration in male rats. One hundred male albino rats were …

Introduction: Tramadol is a centrally acting analgesic used for treatment of moderate to
severe pain. There has been some controversy regarding the dependence lability of long …

Purpose: The therapeutic benefit derived from the clinical use of tramadol (TD) has been
characterized by hepatotoxicity due to misuse and abuse. The implications of drug-induced …

Tramadol, a broadly used opioid in recent years, is an effective analgesic agent for the
treatment of moderately severe acute or chronic pain. The liver and kidneys are responsible …