Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism

MY Pepino, O Kuda, D Samovski… - Annual review of …, 2014 - annualreviews.org
CD36 (cluster of differentiation 36) is a scavenger receptor that functions in high-affinity
tissue uptake of long-chain fatty acids (FAs) and contributes under excessive fat supply to …

CD36 favours fat sensing and transport to govern lipid metabolism

Y Li, X Huang, G Yang, K Xu, Y Yin, G Brecchia… - Progress in lipid …, 2022 - Elsevier
CD36, located on the cell membrane, transports fatty acids in response to dietary fat. It is a
critical fatty acid sensor and regulator of lipid metabolism. The interaction between CD36 …

Role of CD36 in membrane transport of long-chain fatty acids

A Ibrahimi, NA Abumrad - Current opinion in clinical nutrition & …, 2002 - journals.lww.com
CD36 is a multispecific membrane glycoprotein that has been postulated to have a variety of
functions. Evidence generated in isolated cells and in mice and rat models of altered CD36 …

Cellular fatty acid uptake: a pathway under construction

X Su, NA Abumrad - Trends in Endocrinology & Metabolism, 2009 - cell.com
Membrane uptake of long-chain fatty acids (FAs) is the first step in cellular FA utilization and
a point of metabolic regulation. CD36 facilitates a major fraction of FA uptake by key tissues …

[HTML][HTML] CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood

VA Drover, M Ajmal, F Nassir… - The Journal of …, 2005 - Am Soc Clin Investig
CD36 mediates the transfer of fatty acids (FAs) across the plasma membranes of muscle and
adipose cells, thus playing an important role in regulating peripheral FA metabolism in vivo …

The emerging roles of fatty acid translocase/CD36 and the aryl hydrocarbon receptor in fatty liver disease

J He, JH Lee, M Febbraio… - Experimental Biology and …, 2011 - journals.sagepub.com
The fatty acid translocase (FAT)/CD36 belongs to the class B scavenger receptor family. In
addition to the known functions of CD36 in the uptake of oxidized low-density lipoprotein by …

CD36 is important for adipocyte recruitment and affects lipolysis

IOCM Vroegrijk, JB van Klinken, JA van Diepen… - …, 2013 - Wiley Online Library
Objective: The scavenger receptor CD36 facilitates the cellular uptake of long‐chain fatty
acids. As CD36‐deficiency attenuates the development of high fat diet (HFD)‐induced …

[HTML][HTML] CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin

S Sundaresan, R Shahid, TE Riehl, R Chandra… - The FASEB …, 2013 - ncbi.nlm.nih.gov
Genetic variants in the fatty acid (FA) translocase FAT/CD36 associate with abnormal
postprandial lipids and influence risk for the metabolic syndrome. CD36 is abundant on …

[HTML][HTML] Dynamic role of the transmembrane glycoprotein CD36 (SR-B2) in cellular fatty acid uptake and utilization

JFC Glatz, JJFP Luiken - Journal of lipid research, 2018 - ASBMB
The widely expressed transmembrane glycoprotein, cluster of differentiation 36 (CD36), a
scavenger receptor class B protein (SR-B2), serves many functions in lipid metabolism and …

CD36 enhances fatty acid uptake by increasing the rate of intracellular esterification but not transport across the plasma membrane

S Xu, A Jay, K Brunaldi, N Huang, JA Hamilton - Biochemistry, 2013 - ACS Publications
CD36 is a multifunctional protein that enhances cellular fatty acid (FA) uptake, a key step in
energy metabolism, and its dysregulation in multiple tissue sites is central to obesity-linked …