The unfolded protein response (UPR) is a highly conserved protein quality control
mechanism, activated in response to Endoplasmic Reticulum (ER) stress. Signalling is …

The unfolded protein response (UPR) is a stress response of the endoplasmic reticulum
(ER) to a disturbance in protein folding. The so-called ER stress sensors PERK, IRE1 and …

The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …

Protein translation and folding are tightly controlled processes in all cells, by proteostasis, an
important component of which is the unfolded protein response (UPR). During periods of …

The unfolded protein response (UPR) plays a vital role in maintaining cell homeostasis as a
consequence of endoplasmic reticulum (ER) stress. However, prolonged UPR activity leads …

The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate
levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well …

Activation of the unfolded protein response is emerging as a common theme in protein-
misfolding neurodegenerative diseases, with relevant markers observed in patient tissue …

Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), and the rarer prion diseases, share a number of key similarities …

In eukaryotic cells, the endoplasmic reticulum (ER) is the cell compartment involved in
secretory protein translocation and quality control of secretory protein folding. Different …

Activation of the unfolded protein response (UPR) is emerging as a common theme in
neurodegenerative diseases, seen in both human brain tissue and mouse models. Genetic …