The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

A variety of pathophysiological situations that affect cells of the vasculature, including
endothelial and smooth muscle cells, leads to the expression of genes such as adhesion …

During the acute inflammatory response, there is induction of a mediator cascade which
functions to activate residential macrophages and recruit blood leukocytes to the site of the …

Although the role of NF-κB in the pathogenesis of sepsis and septic shock has been
extensively studied, little is known about the causative contribution of endothelial-intrinsic …

Atherosclerosis is an inflammatory disease, characterized by the accumulation of
macrophage-derived foam cells in the vessel wall and accompanied by the production of a …

The nuclear factor-κB (NF-κB) signalling pathway regulates immune responses and is
implicated in the pathogenesis of many inflammatory diseases. Given the well established …

The ability to sense and adjust to the environment is crucial to life. For multicellular
organisms, the ability to respond to external changes is essential not only for survival but …

Nuclear factor κB (NF-κB) is a dimeric transcription factor constituted by two of five protein
family members. It plays an essential role in inflammation and immunity by regulating the …

NF-κB is a family of structurally related and evolutionarily conserved transcription factors.
There are five NF-κB proteins in mammals: RelAIp65, RelB, c-Rel, NF-κB1 (p50 and its …

Although the role of systemic activation of the nuclear factor κB (NF-κB) pathway in septic
coagulation has been well documented, little is known about the contribution of endothelial …