Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission
The K-Cl co-transporter KCC2 plays multiple roles in the physiology of central neurons and
alterations of its function and/or expression are associated with several neurological …
alterations of its function and/or expression are associated with several neurological …
Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2
I Medina, P Friedel, C Rivera, KT Kahle… - Frontiers in cellular …, 2014 - frontiersin.org
In the mammalian central nervous system (CNS), the inhibitory strength of chloride (Cl−)-
permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular …
permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular …
Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2
The activity of the neuronal-specific potassium chloride co-transporter KCC2 allows neurons
to maintain low intracellular Cl− concentrations. These low Cl− concentrations are critical in …
to maintain low intracellular Cl− concentrations. These low Cl− concentrations are critical in …
Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons
The neuronal K/Cl transporter KCC2 exports chloride ions and thereby influences the
efficacy and polarity of GABA signaling in the brain. KCC2 is also critical for dendritic spine …
efficacy and polarity of GABA signaling in the brain. KCC2 is also critical for dendritic spine …
A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2
The neuronal K-Cl cotransporter KCC2 maintains the low intracellular chloride concentration
required for the hyperpolarizing actions of inhibitory neurotransmitters γ-aminobutyric acid …
required for the hyperpolarizing actions of inhibitory neurotransmitters γ-aminobutyric acid …
Cation-chloride cotransporters in neuronal communication
E Delpire - Physiology, 2000 - journals.physiology.org
Two isoforms of the cation-Cl–cotransporter family are expressed in neurons and modulate
neurotransmission. NKCC1, a Na+-K+-2Cl–cotransporter, by raising internal Cl–, is …
neurotransmission. NKCC1, a Na+-K+-2Cl–cotransporter, by raising internal Cl–, is …
The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines
The K-Cl cotransporter KCC2 plays an essential role in neuronal chloride homeostasis, and
thereby influences the efficacy and polarity of GABA signaling. Although KCC2 is expressed …
thereby influences the efficacy and polarity of GABA signaling. Although KCC2 is expressed …
Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2
KT Kahle, TZ Deeb, M Puskarjov, L Silayeva… - Trends in …, 2013 - cell.com
The K–Cl cotransporter KCC2 establishes the low intraneuronal Cl–levels required for the
hyperpolarizing inhibitory postsynaptic potentials mediated by ionotropic γ-aminobutyric …
hyperpolarizing inhibitory postsynaptic potentials mediated by ionotropic γ-aminobutyric …
Localization of the K+–Cl− cotransporter, KCC3, in the central and peripheral nervous systems: expression in the choroid plexus, large neurons and white matter tracts
Na+-independent K+–Cl− cotransporters function in the regulation of cell volume, control of
CNS excitability and epithelial ion transport. Several K+–Cl− cotransporter isoforms are …
CNS excitability and epithelial ion transport. Several K+–Cl− cotransporter isoforms are …
Reciprocal regulation of KCC2 trafficking and synaptic activity
E Côme, M Heubl, EJ Schwartz, JC Poncer… - Frontiers in Cellular …, 2019 - frontiersin.org
The main inhibitory neurotransmitter receptors in the adult central nervous system (CNS) are
type A γ-aminobutyric acid receptors (GABAARs) and glycine receptors (GlyRs). Synaptic …
type A γ-aminobutyric acid receptors (GABAARs) and glycine receptors (GlyRs). Synaptic …