STS markers spanning the AZFc region of human Y Chromosome (Chr) were used to isolate
a series of 14 P1 artificial chromosome (PAC) clones covering at least 560 kb of DNA. End …

It is widely believed that most or all Y–chromosomal genes were once shared with the X
chromosome. The DAZ gene is a candidate for the human Y–chromosomal Azoospermia …

The human Y chromosome contains over 60 million nucleotides, but least number of genes
compared to any other chromosome and acts as a genetic determinant of the male …

Deletions of the AZFc interval of the human Y chromosome are found in> 5% of male
patients with idiopathic infertility and are associated with a severely reduced sperm count …

Deletion of the entire AZFc locus on the human Y chromosome leads to male infertility. The
functional roles of the individual gene families mapped to AZFc are, however, still poorly …

It was suggested by Ronald Fisher in 1931 that genes that benefit the male (including those
required for spermatogenesis) would accumulate on the Y chromosome. Following the …

The azoospermia factor c (AZFc) region of the Y chromosome consists of repetitive
amplicons and is therefore highly susceptible to structural rearrangements, such as …

The DAZ genes are candidate fertility factors that lie within the human Y chromosome's AZFc
region, whose deletion is a common cause of spermatogenic failure. The number of DAZ …

Microdeletions of the Y chromosome long arm are the most common mutations in infertile
males, where they involve one or more “azoospermia factors”(AZFa, b, and c) …

Using a positional cloning approach, we have isolated a new gene family, the Y-located
RNA Recognition Motif genes (YRRM), which constitutes a candidate for AZF …