cGMP controls many cellular functions ranging from growth, viability, and differentiation to
contractility, secretion, and ion transport. The mammalian genome encodes seven …

Besides soluble guanylyl cyclase (GC), the receptor for NO, there are at least seven plasma
membrane enzymes that synthesize the second-messenger cGMP. All membrane GCs (GC …

Guanylyl cyclases are a family of enzymes that catalyze the conversion of GTP to cGMP. The
family comprises both membrane-bound and soluble isoforms that are expressed in nearly …

Guanylyl cyclases (GCs) are enzymes that convert guanosine-5′-triphosphate (GTP) to
cyclic guanosine-3′, 5′-monophosphate (cGMP). The second messenger cGMP …

Cyclic GMP is a ubiquitous second messenger that regulates a wide array of physiologic
processes such as blood pressure, long bone growth, intestinal fluid secretion …

Soon after the discovery of cAMP, cGMP was detected in urine (Ashman et al. 1963), and,
later on, was shown to be formed in practically all cells and tissues (Hardman and …

Nitric oxide, bicarbonate, natriuretic peptides (ANP, BNP and CNP), guanylins, uroguanylins
and guanylyl cyclase activating proteins (GCAPs) activate a family of enzymes variously …

Recent studies have demonstrated key roles for several membrane guanylyl cyclase
receptors in the regulation of cell hyperplasia, hypertrophy, migration and extracellular …

The mammalian main olfactory epithelium (MOE) recognizes and transduces olfactory cues
through a G protein-coupled, cAMP-dependent signaling cascade. Additional chemosensory …

The guanylate cyclase-activating proteins (GCAPs), Ca2+-binding proteins of the calmodulin
gene superfamily, function as regulators of photoreceptor guanylate cyclases. In contrast to …