Angiotensin‐converting enzymes as druggable features of psychiatric and neurodegenerative disorders
TC Santiago, L Parra, JV Nani… - Journal of …, 2023 - Wiley Online Library
The renin‐angiotensin system (RAS) plays essential roles in maintaining peripheral
cardiovascular homeostasis, with its potential roles in the brain only being recognized more …
cardiovascular homeostasis, with its potential roles in the brain only being recognized more …
Brain angiotensin converting enzyme-2 in central cardiovascular regulation
The brain renin–angiotensin system (RAS) plays an important role in the regulation of
autonomic and neuroendocrine functions, and maintains cardiovascular homeostasis. Ang-II …
autonomic and neuroendocrine functions, and maintains cardiovascular homeostasis. Ang-II …
Targeting the renin-angiotensin system (RAS) for neuropsychiatric disorders
Background: Neuropsychiatric disorders, such as mood disorders, schizophrenia, and
Alzheimer's disease (AD) and related dementias, are associated to significant morbidity and …
Alzheimer's disease (AD) and related dementias, are associated to significant morbidity and …
Angiotensin-converting enzyme as a potential target for treatment of Alzheimer's disease: inhibition or activation?
K Zou, M Michikawa - Reviews in the Neurosciences, 2008 - degruyter.com
The accumulation of the amyloid ß-protein (Aß), the main constituent of the'amyloid plaque',
is widely considered to be the key pathological event in Alzheimer's disease (AD). In …
is widely considered to be the key pathological event in Alzheimer's disease (AD). In …
A role for the brain RAS in Alzheimer's and Parkinson's diseases
JW Wright, LH Kawas, JW Harding - Frontiers in endocrinology, 2013 - frontiersin.org
The brain renin-angiotensin system (RAS) has available the necessary functional
components to produce the active ligands angiotensins II (AngII), angiotensin III …
components to produce the active ligands angiotensins II (AngII), angiotensin III …
Cerebroprotective effects of RAS inhibitors: Beyond their cardio-renal actions
Work on the brain renin–angiotensin system has been explored by various researchers and
has led to elucidation of its basic physiologies and behavior, including its role in …
has led to elucidation of its basic physiologies and behavior, including its role in …
The implications of angiotensin-converting enzymes and their modulators in neurodegenerative disorders: current and future perspectives
P Kaur, A Muthuraman, M Kaur - ACS chemical neuroscience, 2015 - ACS Publications
Angiotensin converting enzyme (ACE) is a dipeptidyl peptidase transmembrane bound
enzyme. Generally, ACE inhibitors are used for the cardiovascular disorders. ACE inhibitors …
enzyme. Generally, ACE inhibitors are used for the cardiovascular disorders. ACE inhibitors …
Brain renin–angiotensin system as novel and potential therapeutic target for Alzheimer's disease
R Loera-Valencia, F Eroli, S Garcia-Ptacek… - International journal of …, 2021 - mdpi.com
The activation of the brain renin-angiotensin system (RAS) plays a pivotal role in the
pathophysiology of cognition. While the brain RAS has been studied before in the context of …
pathophysiology of cognition. While the brain RAS has been studied before in the context of …
Renin-angiotensin system and Alzheimer's disease pathophysiology: from the potential interactions to therapeutic perspectives
VT Ribeiro, LC de Souza… - Protein and Peptide …, 2020 - ingentaconnect.com
New roles of the Renin-Angiotensin System (RAS), apart from fluid homeostasis and Blood
Pressure (BP) regulation, are being progressively unveiled, since the discoveries of RAS …
Pressure (BP) regulation, are being progressively unveiled, since the discoveries of RAS …
Recent advances in the endogenous brain renin-angiotensin system and drugs acting on it
The RAS (renin-angiotensin system) is the part of the endocrine system that plays a prime
role in the control of essential hypertension. Since the discovery of brain RAS in the …
role in the control of essential hypertension. Since the discovery of brain RAS in the …