Ectopic expression of 35 kDa and knocking down of 78 kDa SG2NAs induce cytoskeletal reorganization, alter membrane sialylation, and modulate the markers of EMT
SG2NA is a protein of the striatin family that organizes STRIPAK complexes. It has splice
variants expressing differentially in tissues. Its 78 kDa isoform regulates cell cycle, maintains …
variants expressing differentially in tissues. Its 78 kDa isoform regulates cell cycle, maintains …
Subcellular dynamics of variants of SG2NA in NIH3T3 fibroblasts
Abstract SG2NA, a WD40 repeat protein of the Striatin subfamily, has four splicing and one
messenger RNA edit variants. It is fast emerging as a scaffold for multimeric signaling …
messenger RNA edit variants. It is fast emerging as a scaffold for multimeric signaling …
The profile of expression of the scaffold protein SG2NA (s) differs between cancer types and its interactome in normal vis-a-vis breast tumor tissues suggests its wide …
Striatin and SG2NA are scaffold proteins that form signaling complexes called STRIPAK. It
has been associated with developmental abnormalities, cancer, and several other diseases …
has been associated with developmental abnormalities, cancer, and several other diseases …
WD-40 repeat protein SG2NA has multiple splice variants with tissue restricted and growth responsive properties
M Sanghamitra, I Talukder, N Singarapu, KV Sindhu… - Gene, 2008 - Elsevier
SG2NA is a member of the striatin family of WD-40 repeat proteins with potential scaffolding
functions. It was originally identified as a tumor antigen with increased expression during S …
functions. It was originally identified as a tumor antigen with increased expression during S …
[HTML][HTML] Striatin family proteins: the neglected scaffolds
The Striatin family of proteins constitutes Striatin, SG2NA, and Zinedin. Members of this
family of proteins act as a signaling scaffold due to the presence of multiple protein-protein …
family of proteins act as a signaling scaffold due to the presence of multiple protein-protein …
GSK3β and ERK regulate the expression of 78 kDa SG2NA and ectopic modulation of its level affects phases of cell cycle
Striatin and SG2NA are essential constituents of the multi-protein STRIPAK assembly
harbouring protein phosphatase PP2A and several kinases. SG2NA has several isoforms …
harbouring protein phosphatase PP2A and several kinases. SG2NA has several isoforms …
Cellular impacts of striatins and the STRIPAK complex and their roles in the development and metastasis in clinical cancers
Simple Summary The STRIPAK (striatin-interacting phosphatase and kinase) complex and
its central components, striatins (STRNs), have attracted significant interest with regard to …
its central components, striatins (STRNs), have attracted significant interest with regard to …
Molecular modeling and molecular dynamics simulations based structural analysis of the SG2NA protein variants
Background SG2NA is a member of the striatin sub-family of WD-40 repeat proteins. Striatin
family members have been associated with diverse physiological functions. SG2NA has also …
family members have been associated with diverse physiological functions. SG2NA has also …
Silencing of STRN 4 suppresses the malignant characteristics of cancer cells
M Wong, T Hyodo, E Asano, K Funasaka… - Cancer …, 2014 - Wiley Online Library
The striatin family of proteins, comprising STRN, STRN 3 and STRN 4, are multidomain‐
containing proteins that associate with additional proteins to form a large protein complex …
containing proteins that associate with additional proteins to form a large protein complex …
siRNA gelsolin knockdown induces epithelial‐mesenchymal transition with a cadherin switch in human mammary epithelial cells
H Tanaka, R Shirkoohi, K Nakagawa… - … journal of cancer, 2006 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) describes a process occurring during development
and oncogenesis by which epithelial cells obtain fibroblast‐like properties and show …
and oncogenesis by which epithelial cells obtain fibroblast‐like properties and show …