Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

SY Lunt, MG Vander Heiden - Annual review of cell and …, 2011 - annualreviews.org
Warburg's observation that cancer cells exhibit a high rate of glycolysis even in the presence
of oxygen (aerobic glycolysis) sparked debate over the role of glycolysis in normal and …

Limits of aerobic metabolism in cancer cells

J Fernandez-de-Cossio-Diaz, A Vazquez - Scientific reports, 2017 - nature.com
Cancer cells exhibit high rates of glycolysis and glutaminolysis. Glycolysis can provide
energy and glutaminolysis can provide carbon for anaplerosis and reductive carboxylation …

Aerobic glycolysis: beyond proliferation

W Jones, K Bianchi - Frontiers in immunology, 2015 - frontiersin.org
Aerobic glycolysis has been generally associated with cancer cell proliferation, but
fascinating and novel data show that it is also coupled to a series of further cellular functions …

[HTML][HTML] Mitochondrial and metabolic alterations in cancer cells

J Di Gregorio, S Petricca, R Iorio, E Toniato… - European journal of cell …, 2022 - Elsevier
Metabolic alterations have been observed in many cancer types. The deregulated
metabolism has thus become an emerging hallmark of the disease, where the metabolism is …

Cancer's fuel choice: new flavors for a picky eater

GM DeNicola, LC Cantley - Molecular cell, 2015 - cell.com
Otto Warburg discovered that cancer cells exhibit a high rate of glycolysis in the presence of
ample oxygen, a process termed aerobic glycolysis, in 1924 (Warburg et al., 1924). Since …

Glucose metabolism in cancer cells

A Annibaldi, C Widmann - Current Opinion in Clinical Nutrition & …, 2010 - journals.lww.com
Glucose metabolism in cancer cells : Current Opinion in Clinical Nutrition & Metabolic Care
Glucose metabolism in cancer cells : Current Opinion in Clinical Nutrition & Metabolic Care Log …

Molecular intricacies of aerobic glycolysis in cancer: current insights into the classic metabolic phenotype

S Ganapathy-Kanniappan - Critical reviews in biochemistry and …, 2018 - Taylor & Francis
Aerobic glycolysis is the process of oxidation of glucose into pyruvate followed by lactate
production under normoxic condition. Distinctive from its anaerobic counterpart (ie glycolysis …

Catabolic efficiency of aerobic glycolysis: the Warburg effect revisited

A Vazquez, J Liu, Y Zhou, ZN Oltvai - BMC systems biology, 2010 - Springer
Background Cancer cells simultaneously exhibit glycolysis with lactate secretion and
mitochondrial respiration even in the presence of oxygen, a phenomenon known as the …

Cancer metabolism: facts, fantasy, and fiction

XL Zu, M Guppy - Biochemical and biophysical research communications, 2004 - Elsevier
The concept of a glycolytic cancer cell was introduced by Warburg over 70 years ago. This
perception has since become the rationale that drives a considerable proportion of basic …

'Why do tumour cells glycolyse?': from glycolysis through citrate to lipogenesis

LC Costello, RB Franklin - Molecular and cellular biochemistry, 2005 - Springer
The re-emergence of interest in intermediary metabolism and the development of
metabolomics in relation to cancer and other diseases provide a timely reason to revisit …