The potential remedy of melatonin on osteoarthritis

KH Lu, PWA Lu, EWH Lu, CH Tang… - Journal of Pineal …, 2021 - Wiley Online Library
Osteoarthritis (OA), the most common arthritis worldwide, is a degenerative joint disease
characterized by progressive cartilage breakdown, subchondral remodeling, and synovial …

Melatonin: A novel candidate for the treatment of osteoarthritis

Y Zhang, T Liu, H Yang, F He, X Zhu - Ageing research reviews, 2022 - Elsevier
Osteoarthritis (OA), characterized by cartilage erosion, synovium inflammation, and
subchondral bone remodeling, is a common joint degenerative disease worldwide. OA …

Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes

R Jahanban‐Esfahlan, S Mehrzadi… - British journal of …, 2018 - Wiley Online Library
Rheumatoid arthritis (RA) and osteoarthritis (OA) are the two most prevalent joint diseases.
A such, they are important causes of pain and disability in a substantial proportion of the …

Melatonin attenuates TNF‐α and IL‐1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis

CC Huang, CH Chiou, SC Liu, SL Hu… - Journal of pineal …, 2019 - Wiley Online Library
The hormone melatonin has many properties, including antioxidant, anti‐inflammatory, and
immunomodulatory effects. Melatonin has been demonstrated to be beneficial in several …

Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin

A Hosseinzadeh, SK Kamrava… - Journal of pineal …, 2016 - Wiley Online Library
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive erosion of
articular cartilage. As chondrocytes are the only cell type forming the articular cartilage, their …

[HTML][HTML] Role of melatonin combined with exercise as a switch-like regulator for circadian behavior in advanced osteoarthritic knee

Y Hong, H Kim, S Lee, Y Jin, J Choi, SR Lee… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Here, we show the role of melatonin combined with or without exercise as a determinant of
multicellular behavior in osteoarthritis. We address the relationship between the molecular …

Reconsidering the role of melatonin in rheumatoid arthritis

IJ MacDonald, CC Huang, SC Liu, CH Tang - International journal of …, 2020 - mdpi.com
Rheumatoid arthritis (RA) is an inflammatory joint disorder characterized by synovial
proliferation and inflammation, with eventual joint destruction if inadequately treated …

Melatonin abolished proinflammatory factor expression and antagonized osteoarthritis progression in vivo

SC Liu, CH Tsai, YH Wang, CM Su, HC Wu… - Cell Death & …, 2022 - nature.com
Progressive structural changes in osteoarthritis (OA) involve synovial inflammation and
angiogenesis, as well as activation of the proinflammatory cytokines tumor necrosis factor …

Melatonin prevents osteoarthritis‐induced cartilage degradation via targeting MicroRNA‐140

Y Zhang, J Lin, X Zhou, X Chen… - Oxidative medicine …, 2019 - Wiley Online Library
Osteoarthritis (OA) is characterized by the progressive destruction of articular cartilage,
which is involved in the imbalance between extracellular matrix (ECM) synthesis and …

Physiological and pathological role of circadian hormones in osteoarthritis: dose-dependent or time-dependent?

FM Hossain, Y Hong, Y Jin, J Choi, Y Hong - Journal of clinical medicine, 2019 - mdpi.com
Osteoarthritis (OA), the most common form of arthritis, may be triggered by improper
secretion of circadian clock-regulated hormones, such as melatonin, thyroid-stimulating …