Among non-viral vectors, chitosan and chitosan derivatives have been developed in vitro
and in vivo for DNA and siRNA delivery systems because of their cationic charge …

Currently, the major drawback of gene therapy is the gene transfection rate. The two main
types of vectors that are used in gene therapy are based on viral or non-viral gene delivery …

Recently, chitosan has attracted significant attention in the formulation of small interfering
RNA (siRNA). Because of its cationic nature, chitosan can easily complex siRNA, thus …

Gene therapy is a promising strategy for treating challenging diseases. The successful
delivery of genes is a critical step for gene therapy. However, concerns about …

Chitosan (CS) shows in vitro and in vivo efficacy for siRNA delivery but with contradictory
findings for incompletely characterized systems. For understanding which parameters …

Chitosan is a naturally occurring cationic mucopolysaccharide. It is generally biocompatible,
biodegradable, mucoadhesive, non-immunogenic and non-toxic. Although chitosan is able …

Chitosan can be useful as a nonviral vector for gene delivery. Although there are several
reports to form chitosan-pDNA particles, the optimization and effect on transfection remain …

Regarding safety concerns, nonviral gene delivery vehicles that have the required efficiency
and safety for use in human gene therapy are being widely investigated. The aim of this …

Currently, the success of gene therapy is mainly limited due to the lack of effective vector
systems. Although viral vectors are highly efficient in transfecting cells, undesirable …

This study aims at developing chitosan-based nanoparticles suitable for an intravenous
administration of small interfering RNA (siRNA) able to achieve (i) high gene silencing …