Genistein prevents development of spontaneous ovarian cancer and inhibits tumor growth in hen model

K Sahin, E Yenice, B Bilir, C Orhan, M Tuzcu… - Cancer Prevention …, 2019 - AACR
Genistein, the major isoflavone in soybean, has been reported to exert anticancer effects on
various types of cancer including ovarian cancer; however, its chemopreventive effects and …

[HTML][HTML] Chemopreventive and chemotherapeutic effects of genistein, a soy isoflavone, upon cancer development and progression in preclinical animal models

SH Kim, CW Kim, SY Jeon, RE Go… - Laboratory animal …, 2014 - synapse.koreamed.org
Genistein is one of isoflavones mostly derived in a leguminous plant. It is well known as one
of phytoestrogens that have structures similar to the principal mammalian estrogen. It has …

Genistein upregulates cyclin D1 and CDK4 expression and promotes the proliferation of ovarian cancer OVCAR-5 cells

Y Wang, W Li, Z Wang, H Ren, Y Li, Y Zhang, P Yang… - Clinica Chimica …, 2021 - Elsevier
Background Ovarian epithelial cancer is the leading cause of deaths associated with
gynecologic malignancies. Genistein represents a major type of phytoestrogens widely …

[HTML][HTML] Genistein as a potential anticancer agent against ovarian cancer

JY Lee, HS Kim, YS Song - Journal of Traditional and Complementary …, 2012 - Elsevier
Genistein is known as the major component of isoflavone, which is present in high-soy diets.
Genistein has received much attention because of its chemopreventive and therapeutic …

[HTML][HTML] Genistein chemoprevention: timing and mechanisms of action in murine mammary and prostate

CA Lamartiniere, MS Cotroneo, WA Fritz, J Wang… - The Journal of …, 2002 - Elsevier
We investigated the potential of genistein, the primary isoflavone of soy, to protect against
breast and prostate cancers in animal models. For mammary cancer studies, Sprague …

Mechanisms of cancer chemoprevention by soy isoflavone genistein

FH Sarkar, Y Li - Cancer and Metastasis Reviews, 2002 - Springer
Diet has been implicated to play an important role in cancers. Epidemiological studies have
revealed that Asians, who consume a traditional diet high in soy products, have relatively …

Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells

Z Zhang, CZ Wang, GJ Du, LW Qi… - International …, 2013 - spandidos-publications.com
Soybean isoflavones have been used as a potential preventive agent in anticancer research
for many years. Genistein is one of the most active flavonoids in soybeans. Accumulating …

High Concentrations of Genistein Decrease Cell Viability Depending on Oxidative Stress and Inflammation in Colon Cancer Cell Lines

M Alorda-Clara, M Torrens-Mas… - International journal of …, 2022 - mdpi.com
Genistein could play a crucial role in modulating three closely linked physiological
processes altered during cancer: oxidative stress, mitochondrial biogenesis, and …

Preliminary studies on induction of apoptosis by genistein on HepG2 cell line

D Chodon, N Ramamurty, D Sakthisekaran - Toxicology in vitro, 2007 - Elsevier
Consumption of soy products has been linked to lower the incidence of number of cancers.
Genistein, one of the principal soy isoflavones, has been shown to inhibit the growth of a …

Multi-targeted therapy of cancer by genistein

S Banerjee, Y Li, Z Wang, FH Sarkar - Cancer letters, 2008 - Elsevier
Soy isoflavones have been identified as dietary components having an important role in
reducing the incidence of breast and prostate cancers in Asian countries. Genistein, the …