Background Epidemiological studies have reported conflicting findings on the potential
adverse effects of long-term antihypertensive medication use on cancer risk. Naturally …

Aims/hypothesis Epidemiological studies have generated conflicting findings on the
relationship between glucose-lowering medication use and cancer risk. Naturally occurring …

Dipender Gill and Stephen Burgess discuss the accompanying study by James Yarmolinsky
and colleagues investigating the associations between genetically-proxied inhibition of …

Low-penetrance genetic variations appear to form the most essential component of the
heritability of cancer risk. Search for relevant polymorphic candidates faces significant …

We previously conducted genome-wide association meta-analysis of systolic blood
pressure, diastolic blood pressure, and hypertension in 29 136 people from 6 cohort studies …

Abstract Since 2007, genome-wide association (GWA) studies have identified numerous
well-supported, novel genetic risk loci for common cancers; however, there are concerns …

Background: Many cancers share specific genetic risk factors, including both rare high-
penetrance mutations and common SNPs identified through genome-wide association …

From overenthusiasm to scientific assessment and hard reality, the time required for this
transiton has recently been drastically shortened. As high-throughput screening technology …

Genome-wide association studies (GWAS) have emerged as an important tool for
discovering regions of the genome that harbor genetic variants that confer risk for different …

The clinical use of genetic variation in the evaluation of cancer risk is expanding, and thus
understanding how determinants of cancer susceptibility identified in one population can be …