Most B cells produced in the bone marrow have some level of autoreactivity. Despite efforts
of central tolerance to eliminate these cells, many escape to periphery, where in healthy …

A significant proportion of autoimmune-associated genetic variants are expressed in B cells,
suggesting that B cells may play multiple roles in autoimmune pathogenesis. In this review …

Genome-wide strategies have driven the discovery of more than 300 susceptibility loci for
autoimmune diseases. However, for almost all loci, understanding of the mechanisms …

Autoimmune diseases display a high degree of comorbidity within individuals and families,
suggesting shared risk factors. Over the past 15 years, genome-wide association studies …

In genetic studies of autoimmune and inflammatory diseases, one clear finding that has
emerged from genome-wide association studies is that a substantial fraction of variation …

Autoimmune diseases affect up to approximately 10% of the population. While rare
Mendelian autoimmunity syndromes can result from monogenic mutations disrupting …

The chronic autoimmune diseases include multiple complex genetic disorders. Recently,
genome-wide association studies (GWAS) have identified a large number of major loci, with …

Genome-wide association studies (GWASs) have uncovered hundreds of autoimmune
disease-associated loci; however, the causal genetic variants within each locus are mostly …

Immunoglobulin (IG) genes, encoding B cell receptors (BCRs), are fundamental components
of the mammalian immune system, which evolved to recognize the diverse antigenic …

Genome-wide association studies have identified hundreds of risk variants associated with
human autoimmune diseases. Recent evidence suggests that a substantial portion of them …