[HTML][HTML] Emerging mechanisms of valproic acid-induced neurotoxic events in autism and its implications for pharmacological treatment

A Taleb, W Lin, X Xu, G Zhang, QG Zhou… - Biomedicine & …, 2021 - Elsevier
Autism spectrum disorder (ASD) is a sort of mental disorder marked by deficits in cognitive
and communication abilities. To date no effective cure for this pernicious disease has been …

What we have learned about autism spectrum disorder from valproic acid

T Chomiak, N Turner, B Hu - Pathology research international, 2013 - Wiley Online Library
Two recent epidemiological investigations in children exposed to valproic acid (VPA)
treatment in utero have reported a significant risk associated with neurodevelopmental …

[HTML][HTML] Three decades of valproate: a current model for studying autism Spectrum disorder

D Zarate-Lopez, AL Torres-Chávez… - Current …, 2023 - ncbi.nlm.nih.gov
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with increased
prevalence and incidence in recent decades. Its etiology remains largely unclear, but it …

Neuroimmune alterations in autism: a translational analysis focusing on the animal model of autism induced by prenatal exposure to valproic acid

I Deckmann, GB Schwingel, M Fontes-Dutra… - …, 2019 - karger.com
Autism spectrum disorder (ASD) is a highly prevalent developmental disorder characterized
by deficits in communication and social interaction and in stereotyped or repetitive …

Assessment of behavioral, morphological and electrophysiological changes in prenatal and postnatal valproate induced rat models of autism spectrum disorder

K Fereshetyan, V Chavushyan, M Danielyan… - Scientific reports, 2021 - nature.com
Autism spectrum disorders (ASD) are neurodevelopmental disorders, that are characterized
by core symptoms, such as alterations of social communication and restrictive or repetitive …

Perinatal influences of valproate on brain and behaviour: an animal model for autism

P Ranger, BA Ellenbroek - Neurotoxin Modeling of Brain Disorders—Life …, 2016 - Springer
Valproic acid or valproate (VPA) is an anti-convulsant and mood stabiliser effective in
treating epilepsy and bipolar disorders. Although in adults VPA is well tolerated and safe …

Validation of prenatal versus postnatal valproic acid rat models of autism: A behavioral and neurobiological study

EM Elnahas, SA Abuelezz, MI Mohamad… - Progress in Neuro …, 2021 - Elsevier
Despite the increasing prevalence of autism spectrum disorder (ASD), there is still a
deficiency in understanding its exact pathophysiology and treatment, therefore validation of …

Impaired repair of DNA damage is associated with autistic-like traits in rats prenatally exposed to valproic acid

M Servadio, A Manduca, F Melancia, L Leboffe… - European …, 2018 - Elsevier
Prenatal exposure to the antiepileptic and mood stabilizer valproic acid (VPA) is an
environmental risk factor for autism spectrum disorders (ASD), although recent …

The critical period of valproate exposure to induce autistic symptoms in Sprague–Dawley rats

KC Kim, P Kim, HS Go, CS Choi, SI Yang, JH Cheong… - Toxicology letters, 2011 - Elsevier
Prenatal exposure to valproic acid (VPA) induces neural tube defects and impairment in
social behaviors related to autistic spectrum disorder in newborns, which make it a useful …

Downregulation of glutamatergic and GABAergic proteins in valproric acid associated social impairment during adolescence in mice

DKF Chau, AYT Choi, W Yang, WN Leung… - Behavioural brain …, 2017 - Elsevier
Abstract The etiology of Autism Spectrum Disorder (ASD) remains controversial. Deficits in
social communication are one of the key criteria for ASD diagnosis. Valproic acid (VPA) …