[HTML][HTML] Emerging mechanisms of valproic acid-induced neurotoxic events in autism and its implications for pharmacological treatment
A Taleb, W Lin, X Xu, G Zhang, QG Zhou… - Biomedicine & …, 2021 - Elsevier
Autism spectrum disorder (ASD) is a sort of mental disorder marked by deficits in cognitive
and communication abilities. To date no effective cure for this pernicious disease has been …
and communication abilities. To date no effective cure for this pernicious disease has been …
What we have learned about autism spectrum disorder from valproic acid
T Chomiak, N Turner, B Hu - Pathology research international, 2013 - Wiley Online Library
Two recent epidemiological investigations in children exposed to valproic acid (VPA)
treatment in utero have reported a significant risk associated with neurodevelopmental …
treatment in utero have reported a significant risk associated with neurodevelopmental …
[HTML][HTML] Three decades of valproate: a current model for studying autism Spectrum disorder
D Zarate-Lopez, AL Torres-Chávez… - Current …, 2023 - ncbi.nlm.nih.gov
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with increased
prevalence and incidence in recent decades. Its etiology remains largely unclear, but it …
prevalence and incidence in recent decades. Its etiology remains largely unclear, but it …
Neuroimmune alterations in autism: a translational analysis focusing on the animal model of autism induced by prenatal exposure to valproic acid
I Deckmann, GB Schwingel, M Fontes-Dutra… - …, 2019 - karger.com
Autism spectrum disorder (ASD) is a highly prevalent developmental disorder characterized
by deficits in communication and social interaction and in stereotyped or repetitive …
by deficits in communication and social interaction and in stereotyped or repetitive …
Assessment of behavioral, morphological and electrophysiological changes in prenatal and postnatal valproate induced rat models of autism spectrum disorder
K Fereshetyan, V Chavushyan, M Danielyan… - Scientific reports, 2021 - nature.com
Autism spectrum disorders (ASD) are neurodevelopmental disorders, that are characterized
by core symptoms, such as alterations of social communication and restrictive or repetitive …
by core symptoms, such as alterations of social communication and restrictive or repetitive …
Perinatal influences of valproate on brain and behaviour: an animal model for autism
P Ranger, BA Ellenbroek - Neurotoxin Modeling of Brain Disorders—Life …, 2016 - Springer
Valproic acid or valproate (VPA) is an anti-convulsant and mood stabiliser effective in
treating epilepsy and bipolar disorders. Although in adults VPA is well tolerated and safe …
treating epilepsy and bipolar disorders. Although in adults VPA is well tolerated and safe …
Validation of prenatal versus postnatal valproic acid rat models of autism: A behavioral and neurobiological study
Despite the increasing prevalence of autism spectrum disorder (ASD), there is still a
deficiency in understanding its exact pathophysiology and treatment, therefore validation of …
deficiency in understanding its exact pathophysiology and treatment, therefore validation of …
Impaired repair of DNA damage is associated with autistic-like traits in rats prenatally exposed to valproic acid
M Servadio, A Manduca, F Melancia, L Leboffe… - European …, 2018 - Elsevier
Prenatal exposure to the antiepileptic and mood stabilizer valproic acid (VPA) is an
environmental risk factor for autism spectrum disorders (ASD), although recent …
environmental risk factor for autism spectrum disorders (ASD), although recent …
The critical period of valproate exposure to induce autistic symptoms in Sprague–Dawley rats
Prenatal exposure to valproic acid (VPA) induces neural tube defects and impairment in
social behaviors related to autistic spectrum disorder in newborns, which make it a useful …
social behaviors related to autistic spectrum disorder in newborns, which make it a useful …
Downregulation of glutamatergic and GABAergic proteins in valproric acid associated social impairment during adolescence in mice
Abstract The etiology of Autism Spectrum Disorder (ASD) remains controversial. Deficits in
social communication are one of the key criteria for ASD diagnosis. Valproic acid (VPA) …
social communication are one of the key criteria for ASD diagnosis. Valproic acid (VPA) …