[HTML][HTML] Translational studies on the potential of a VEGF nanoparticle-loaded hyaluronic acid hydrogel

J O'Dwyer, R Murphy, A González-Vázquez… - Pharmaceutics, 2021 - mdpi.com
Heart failure has a five-year mortality rate approaching 50%. Inducing angiogenesis
following a myocardial infarction is hypothesized to reduce cardiomyocyte death and tissue …

Development of a nanomedicine-loaded hydrogel for sustained delivery of an angiogenic growth factor to the ischaemic myocardium

J O'Dwyer, R Murphy, EB Dolan, L Kovarova… - Drug delivery and …, 2020 - Springer
The 5-year mortality rate for heart failure borders on 50%. The main cause is an ischaemic
cardiac event where blood supply to the tissue is lost and cell death occurs. Over time, this …

Dual delivery of VEGF and ANG-1 in ischemic hearts using an injectable hydrogel

AJ Rufaihah, NA Johari, SR Vaibavi, M Plotkin… - Acta biomaterialia, 2017 - Elsevier
Acute myocardial infarction (MI) caused by ischemia is the most common cause of cardiac
dysfunction. While growth factor therapy is promising, the retention in the highly vascularized …

Induction of angiogenesis by controlled delivery of vascular endothelial growth factor using nanoparticles

J Xie, H Wang, Y Wang, F Ren, W Yi… - Cardiovascular …, 2013 - Wiley Online Library
Aims The study reports the feasibility and efficiency of vascular endothelial growth factor
(VEGF) delivery using nanoparticles synthesized from glycidyl methacrylated dextran (D ex …

Sustained VEGF delivery via PLGA nanoparticles promotes vascular growth

JS Golub, Y Kim, CL Duvall… - American Journal …, 2010 - journals.physiology.org
Technologies to increase tissue vascularity are critically important to the fields of tissue
engineering and cardiovascular medicine. Currently, limited technologies exist to encourage …

[HTML][HTML] Dual delivery of hepatocyte and vascular endothelial growth factors via a protease-degradable hydrogel improves cardiac function in rats

AS Salimath, EA Phelps, AV Boopathy, P Che… - PloS one, 2012 - journals.plos.org
Acute myocardial infarction (MI) caused by ischemia and reperfusion (IR) is the most
common cause of cardiac dysfunction due to local cell death and a temporally regulated …

[HTML][HTML] Comparison of the effect of two hyaluronic acid preparations on fibroblast and endothelial cell functions related to angiogenesis

V Ciccone, M Zazzetta, L Morbidelli - Cells, 2019 - mdpi.com
Hyaluronic acid (HA) is used in substitutive and aesthetic medicine with various
applications. Ultrapure absorbable HA (Bioregen®) and a mix of reticulated and free low …

Efficient revascularization by VEGF administration via heparin-functionalized nanoparticle–fibrin complex

YI Chung, SK Kim, YK Lee, SJ Park, KO Cho… - Journal of Controlled …, 2010 - Elsevier
We investigated the angiogenic bioactivity and therapeutic angiogenic effect of vascular
endothelial growth factor (VEGF) administration by the heparin-functionalized nanoparticle …

A novel protein‐engineered hepatocyte growth factor analog released via a shear‐thinning injectable hydrogel enhances post‐infarction ventricular function

AN Steele, L Cai, VN Truong… - Biotechnology and …, 2017 - Wiley Online Library
In the last decade, numerous growth factors and biomaterials have been explored for the
treatment of myocardial infarction (MI). While pre‐clinical studies have demonstrated …

VEGF nanoparticles repair the heart after myocardial infarction

Y Oduk, W Zhu, R Kannappan… - American Journal …, 2018 - journals.physiology.org
Vascular endothelial growth factor (VEGF) is a well-characterized proangiogenic cytokine
that has been shown to promote neovascularization in hearts of patients with ischemic heart …