Matrix metalloproteinase‐9 (MMP‐9) belongs to the MMP family and has been widely
investigated. Excessive MMP‐9 expression can enhance extracellular matrix degradation …

Introduction 3. Metalloproteinases in atherosclerosis 3.1. MMP structure and function 3.2.
MMPs in the atherosclerotic vascular wall 3.3. MMP inhibitors 4. MMP-10 in atherosclerosis …

Plaque rupture is the main cause of acute myocardial infarction and stroke. Atherosclerotic
plaques have been described to be vulnerable and more prone to rupture when they are …

Background Atherosclerosis is a major cause of cerebrovascular disease. Matrix
metalloproteinases (MMPs) play an important role in matrix degradation within the …

Matrix metalloproteinase‐14 (MMP‐14) promotes vulnerable plaque morphology in mice,
whereas tissue inhibitor of metalloproteinases‐3 (TIMP‐3) overexpression is protective …

Aims Growing evidence suggests a close association of plaque angiogenesis with
atherosclerotic plaque formation and progression, and an important role of matrix …

Rationale: Atherosclerotic lesions express matrix metalloproteinase (MMP) 8, which
possesses proteolytic activity on matrix proteins particularly fibrillar collagens and on …

Matrix metalloproteinases (MMP) have been identified in vulnerable areas of atherosclerotic
plaques and may contribute to plaque instability through extracellular matrix degradation …

Background—Matrix metalloproteinase-9 (MMP-9) is involved in atherosclerosis and
elevated MMP-9 activity has been found in unstable plaques, suggesting a crucial role in …

Objective—Several matrix metalloproteinases (MMPs) have been implicated in extracellular
matrix destruction and other actions that lead to plaque rupture and myocardial infarction …