[HTML][HTML] Pannexin 1 facilitates arterial relaxation via an endothelium-derived hyperpolarization mechanism
D Gaynullina, VI Shestopalov, Y Panchin, OS Tarasova - FEBS letters, 2015 - Elsevier
Abstract Pannexin 1 (Panx1) is involved in endothelium-dependent vasodilation in large
arteries, but the exact mechanistic role remains poorly understood. We hypothesized that …
arteries, but the exact mechanistic role remains poorly understood. We hypothesized that …
Pannexin 1 in the regulation of vascular tone
M Billaud, JK Sandilos, BE Isakson - Trends in cardiovascular medicine, 2012 - Elsevier
Pannexins are a recently discovered protein family with the isoform Panx1 ubiquitously
expressed and therefore extensively studied. Panx1 proteins form membrane channels …
expressed and therefore extensively studied. Panx1 proteins form membrane channels …
[HTML][HTML] Endothelial function is impaired in conduit arteries of pannexin1 knockout mice
D Gaynullina, OS Tarasova, OO Kiryukhina… - Biology direct, 2014 - Springer
Pannexin1 is ubiquitously expressed in vertebrate tissues, but the role it plays in vascular
tone regulation remains unclear. We found that Pannexin1 expression level is much higher …
tone regulation remains unclear. We found that Pannexin1 expression level is much higher …
Novel pannexin‐1‐coupled signaling cascade involved in the control of endothelial cell function and NO‐dependent relaxation
Deletion of pannexin‐1 (Panx‐1) leads not only to a reduction in endothelium‐derived
hyperpolarization but also to an increase in NO‐mediated vasodilation. Therefore, we …
hyperpolarization but also to an increase in NO‐mediated vasodilation. Therefore, we …
Pannexin1 regulates α1-adrenergic receptor–mediated vasoconstriction
Rationale: The coordination of vascular smooth muscle cell constriction plays an important
role in vascular function, such as regulation of blood pressure; however, the mechanism …
role in vascular function, such as regulation of blood pressure; however, the mechanism …
A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells
Both purinergic signaling through nucleotides such as ATP (adenosine 5′-triphosphate)
and noradrenergic signaling through molecules such as norepinephrine regulate vascular …
and noradrenergic signaling through molecules such as norepinephrine regulate vascular …
[HTML][HTML] Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane
LJ DeLalio, M Billaud, CA Ruddiman… - Journal of Biological …, 2019 - ASBMB
Pannexin 1 (PANX1)-mediated ATP release in vascular smooth muscle coordinates α1-
adrenergic receptor (α1-AR) vasoconstriction and blood pressure homeostasis. We recently …
adrenergic receptor (α1-AR) vasoconstriction and blood pressure homeostasis. We recently …
Expression of pannexin isoforms in the systemic murine arterial network
Aims: Pannexins (Panx) form ATP release channels and it has been proposed that they play
an important role in the regulation of vascular tone. However, distribution of Panx across the …
an important role in the regulation of vascular tone. However, distribution of Panx across the …
Emerging concepts regarding pannexin 1 in the vasculature
ME Good, D Begandt, LJ DeLalio… - Biochemical Society …, 2015 - portlandpress.com
Pannexin channels are newly discovered ATP release channels expressed throughout the
body. Pannexin 1 (Panx1) channels have become of great interest as they appear to …
body. Pannexin 1 (Panx1) channels have become of great interest as they appear to …
Amount of Pannexin 1 in Smooth Muscle Cells Regulates Sympathetic Nerve–Induced Vasoconstriction
LS Dunaway, M Billaud, E Macal, ME Good… - …, 2023 - Am Heart Assoc
Background: Panx1 (pannexin 1) forms high conductance channels that secrete ATP upon
stimulation. The role of Panx1 in mediating constriction in response to direct sympathetic …
stimulation. The role of Panx1 in mediating constriction in response to direct sympathetic …