Antinuclear antibody testing—misunderstood or misbegotten?

DS Pisetsky - Nature Reviews Rheumatology, 2017 - nature.com
Antinuclear antibodies (ANAs) are a diverse group of autoantibodies that recognize nuclear
macromolecules and their complexes. ANAs represent key biomarkers in the evaluation of …

Understanding and interpreting antinuclear antibody tests in systemic rheumatic diseases

X Bossuyt, E De Langhe, MO Borghi… - Nature Reviews …, 2020 - nature.com
Antinuclear antibodies (ANAs) are valuable laboratory markers to screen for and support the
diagnosis of various rheumatic diseases (known as ANA-associated rheumatic diseases) …

[HTML][HTML] Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?

DS Pisetsky - Arthritis Research & Therapy, 2011 - Springer
Antinuclear antibodies (ANAs) are venerable biomarkers for assessing the diagnosis and
prognosis of patients with autoimmunity. While closely associated with diseases such as …

[HTML][HTML] Emerging technologies in autoantibody testing for rheumatic diseases

NJ Olsen, MY Choi, MJ Fritzler - Arthritis Research & Therapy, 2017 - Springer
Testing for the presence of antinuclear antibodies (ANAs) is a key step in the diagnosis of
systemic lupus erythematosus (SLE) and other systemic autoimmune rheumatic diseases …

Assay variation in the detection of antinuclear antibodies in the sera of patients with established SLE

DS Pisetsky, DM Spencer, PE Lipsky… - Annals of the rheumatic …, 2018 - ard.bmj.com
Objective The expression of antinuclear antibodies (ANA) is considered almost constant in
systemic lupus erythematosus (SLE), although recent experience has suggested that many …

International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies

N Agmon-Levin, J Damoiseaux, C Kallenberg… - Annals of the …, 2014 - ard.bmj.com
Anti-nuclear antibodies (ANA) are fundamental for the diagnosis of autoimmune diseases,
and have been determined by indirect immunofluorescence assay (IIFA) for decades. As the …

New insights into the role of antinuclear antibodies in systemic lupus erythematosus

DS Pisetsky, PE Lipsky - Nature Reviews Rheumatology, 2020 - nature.com
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by
antinuclear antibodies (ANAs) that form immune complexes that mediate pathogenesis by …

Current concepts and future directions for the assessment of autoantibodies to cellular antigens referred to as anti‐nuclear antibodies

M Mahler, PL Meroni, X Bossuyt… - Journal of immunology …, 2014 - Wiley Online Library
The detection of autoantibodies that target intracellular antigens, commonly termed anti‐
nuclear antibodies (ANA), is a serological hallmark in the diagnosis of systemic autoimmune …

Evolving story of autoantibodies in systemic lupus erythematosus

DS Pisetsky - Journal of autoimmunity, 2020 - Elsevier
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by
antinuclear antibody (ANA) production. ANAs bind to DNA, RNA and complexes of proteins …

[PDF][PDF] The antinuclear antibody test: last or lasting gasp?

MJ Fritzler - Arthritis & Rheumatism, 2011 - academia.edu
Autoantibodies have been regarded as a serologic hallmark of systemic autoimmune
rheumatic diseases (ARDs) for more than half a century. Two years following the landmark …