Background Muscle cramps can occur anywhere and for many reasons. Quinine has been
used to treat cramps of all causes. However, controversy continues about its efficacy and …

Background: A Food and Drug Administration advisory in 2006 warned against the off-label
use of quinine sulfate and its derivatives in the treatment of muscle cramps. Physicians are …

Background Although quinine and hydroquinine are commonly prescribed for muscle
cramps, controlled clinical trials of these drugs have reported mixed findings about efficacy …

Background Skeletal muscle cramps affect over a third of the ambulatory elderly population.
Quinine is the established treatment, but there are safety concerns, and evidence for efficacy …

Background Skeletal muscle cramps are common and often occur in association with
pregnancy, advanced age, exercise or motor neuron disorders (such as amyotrophic lateral …

To determine the efficacy and safety of quinine in treating nocturnal muscle cramps we
performed a double‐blind, placebo‐controlled, parallel‐group, multicentre trial in 17 general …

Background Cramps are painful, involuntary muscle contractions. They commonly affect
people with amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) at all stages of …

OBJECTIVE: With respect to the use of quinine for the treatment of nocturnal leg cramps, to
determine whether the findings of a previously performed meta-analysis of published data …

Results We found 12 systematic reviews, RCTs, or observational studies that met our
inclusion criteria. We performed a GRADE evaluation of the quality of evidence for …

Background About one in every three adults are affected by lower limb muscle cramps. For
some people, these cramps reduce quality of life, quality of sleep and participation in …