Vagotomy blunts cardiorespiratory responses to vagal afferent stimulation via pre‐and postsynaptic effects in the nucleus tractus solitarii

GC Hofmann, P Gama de Barcellos Filho… - The Journal of …, 2024 - Wiley Online Library
Viscerosensory information travels to the brain via vagal afferents, where it is first integrated
within the brainstem nucleus tractus solitarii (nTS), a critical contributor to cardiorespiratory …

Unilateral vagotomy alters astrocyte and microglial morphology in the nucleus tractus solitarii of the rat

GC Hofmann, EM Hasser… - American Journal of …, 2021 - journals.physiology.org
The nucleus tractus solitarii (nTS) is the initial site of integration of sensory information from
the cardiorespiratory system and contributes to reflex responses to hypoxia. Afferent fibers of …

The role of astrocytes in the nucleus tractus solitarii in maintaining central control of autonomic function

D Martinez, DD Kline - American Journal of Physiology …, 2021 - journals.physiology.org
The nucleus tractus solitarii (nTS) is the first central site for the termination and integration of
autonomic and respiratory sensory information. Sensory afferents terminating in the nTS as …

Hypoxia activates nucleus tractus solitarii neurons projecting to the paraventricular nucleus of the hypothalamus

TL King, CM Heesch, CG Clark… - American Journal of …, 2012 - journals.physiology.org
Peripheral chemoreceptor afferent information is sent to the nucleus tractus solitarii (nTS),
integrated, and relayed to other brain regions to alter cardiorespiratory function. The nTS …

Gamma-aminobutyric acid transporters in the nucleus tractus solitarii regulate inhibitory and excitatory synaptic currents that influence cardiorespiratory function

D Martinez, L Lima-Silveira, MP Matott… - Frontiers in …, 2022 - frontiersin.org
The brainstem nucleus tractus solitarii (nTS) processes and modulates the afferent arc of
critical peripheral cardiorespiratory reflexes. Sensory afferents release glutamate to initiate …

Paraventricular nucleus projections to the nucleus tractus solitarii are essential for full expression of hypoxia‐induced peripheral chemoreflex responses

BC Ruyle, L Lima‐Silveira, D Martinez… - The Journal of …, 2023 - Wiley Online Library
The hypothalamic paraventricular nucleus (PVN) is essential to peripheral chemoreflex
neurocircuitry, but the specific efferent pathways utilized are not well defined. The PVN …

Role of GABAergic neurones in the nucleus tractus solitarii in modulation of cardiovascular activity

J Zubcevic, JT Potts - Experimental physiology, 2010 - Wiley Online Library
GABAergic neurones are interspersed throughout the nucleus tractus solitarii (NTS), and
their tonic activity is crucial to the maintenance of cardiorespiratory homeostasis. However …

Influence of vagotomy on monosynaptic transmission at second-order nucleus tractus solitarius synapses

JB Swartz, D Weinreich - Journal of neurophysiology, 2009 - journals.physiology.org
Manipulations of vagal activity are used to treat medical pathologies, but the underlying CNS
changes caused by these treatments are not well understood. Furthermore, heart and lung …

Cardiovascular deconditioning increases GABA signaling in the nucleus tractus solitarii

L Lima-Silveira, EM Hasser… - Journal of …, 2022 - journals.physiology.org
The nucleus tractus solitarii (nTS) is the major integrative brainstem region for autonomic
modulation and processing of cardiovascular reflexes. GABA and glutamate are the main …

Mechanisms underlying neuroplasticity in the nucleus tractus solitarii following hindlimb unloading in rats

L Lima-Silveira, D Martinez, EM Hasser, DD Kline - Neuroscience, 2020 - Elsevier
Hindlimb unloading (HU) in rats induces cardiovascular deconditioning (CVD) analogous to
that observed in individuals exposed to microgravity or bed rest. Among other physiological …