Since the early 1950s, the dominant paradigm in the human genetics of infectious diseases
postulates that rare monogenic immunodeficiencies confer vulnerability to multiple infectious …

The observation that only a fraction of individuals infected by infectious agents develop
clinical disease raises fundamental questions about the actual pathogenesis of infectious …

Mutations in human genes involved in immunity are increasingly recognised. Most are
associated with conventional primary immunodeficiencies, which confer Mendelian …

Until the mid-nineteenth century, life expectancy at birth averaged 20 years worldwide,
owing mostly to childhood fevers. The germ theory of diseases then gradually overcame the …

This paper reviews the developments that have occurred in the field of human genetics of
infectious diseases from the second half of the 20th century onward. In particular, it stresses …

Multicellular eukaryotes emerged late in evolution from an ocean of viruses, bacteria,
archaea, and unicellular eukaryotes. These macroorganisms are exposed to and infected by …

For almost any given human-tropic virus, bacterium, fungus, or parasite, the clinical outcome
of primary infection is enormously variable, ranging from asymptomatic to lethal infection …

Recent genome-wide studies have reported novel associations between common
polymorphisms and susceptibility to many major infectious diseases in humans. In parallel …

Infectious pathogens have long been recognized as potentially powerful agents impacting
on the evolution of human genetic diversity. Analysis of large-scale case–control studies …

Infectious diseases represent a major health problem worldwide, both in terms of morbidity
and mortality. A complex combination of environmental, pathogen and host genetic factors …