Aim Proteomics has the potential to enhance early identification of beta-cell dysfunction, in
conjunction with monitoring the various stages of type 2 diabetes onset. The most routine …

ABSTRACT Introduction: Type 1 diabetes (T1D) is characterized by autoimmune-induced
dysfunction and destruction of the pancreatic beta cells. Unfortunately, this process is poorly …

Beta cell-specific surface targets are required for non-invasive monitoring of beta cell mass,
which could be used for evaluation of new diabetes treatments as well as to help unravel …

Purpose Type 1 diabetes (T1D) is characterized by autoimmune mediated self‐destruction
of the pancreatic islet beta cells and the resultant insulin deficiency. However, little is known …

Development of type-2 diabetes (T2D) is preceded by β-cell dysfunction and loss. However,
accurate measurement of β-cell function remains elusive. Biomarkers have been reported to …

Blood markers other than islet autoantibodies are greatly needed to indicate the pancreatic
beta cell destruction process as early as possible, and more accurately reflect the …

Pancreatic beta‐cells have a crucial role in the regulation of blood glucose homeostasis by
the production and secretion of insulin. In type 1 diabetes (T1D), an autoimmune reaction …

Aim The incidence of type 2 diabetes has increased rapidly on a global scale. Beta-cell
dysfunction contributes to the overall pathogenesis of type 2 diabetes. However, factors …

A decline in β-cell function is a prerequisite for the development of type 2 diabetes, yet the
level of β-cell function in individuals at risk of the condition is rarely measured. This is due, in …

The pancreatic beta cell is responsible for maintaining normoglycaemia by secreting an
appropriate amount of insulin according to blood glucose levels. The accurate sensing of the …