Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study

W Huang, J Xiao, J Ji, L Chen - Elife, 2021 - elifesciences.org
Background: Lipid metabolism plays an important role in viral infections. We aimed to
assess the causal effect of lipid-lowering drugs (HMGCR inhibitiors, PCSK9 inhibitiors, and …

HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study

R Bergqvist, VH Ahlqvist, M Lundberg… - PLoS …, 2021 - journals.plos.org
Background The relationship between statin treatment and Coronavirus Disease 2019
(COVID-19) mortality has been discussed due to the pleiotropic effects of statins on …

Association of lipid levels with COVID-19 infection, disease severity and mortality: a systematic review and meta-analysis

V Chidambaram, H Shanmugavel Geetha… - Frontiers in …, 2022 - frontiersin.org
Background Coronavirus disease 2019 (COVID-19) ranges from asymptomatic infection to
severe illness. Cholesterol in the host cell plasma membrane plays an important role in the …

Cholesterol and triglyceride concentrations, COVID-19 severity, and mortality: a systematic review and meta-analysis with meta-regression

A Zinellu, P Paliogiannis, AG Fois, P Solidoro… - Frontiers in public …, 2021 - frontiersin.org
Lipid profile alterations have been observed in patients with coronavirus disease 2019
(COVID-19) in relation to disease severity and mortality. We conducted a systematic review …

Dyslipidemia increases the risk of severe COVID-19: a systematic review, meta-analysis, and meta-regression

IS Atmosudigdo, MA Lim, B Radi… - Clinical Medicine …, 2021 - journals.sagepub.com
Objective: This systematic review and meta-analysis aimed to evaluate whether
dyslipidemia affects the mortality and severity of COVID-19, we also aimed to evaluate …

[HTML][HTML] The potential role of dyslipidemia in COVID-19 severity: an umbrella review of systematic reviews

GJ Choi, HM Kim, H Kang - Journal of Lipid and Atherosclerosis, 2020 - ncbi.nlm.nih.gov
Objective The aim of this study was to analyze the available knowledge about the potential
association between dyslipidemia and the severity of coronavirus disease 2019 (COVID-19) …

Identification of drugs associated with reduced severity of COVID-19–a case-control study in a large population

A Israel, AA Schäffer, A Cicurel, K Cheng, S Sinha… - Elife, 2021 - elifesciences.org
Background: Until coronavirus disease 2019 (COVID-19) drugs specifically developed to
treat COVID-19 become more widely accessible, it is crucial to identify whether existing …

Causal inference for genetic obesity, cardiometabolic profile and COVID-19 susceptibility: a Mendelian randomization study

N Aung, MY Khanji, PB Munroe, SE Petersen - Frontiers in genetics, 2020 - frontiersin.org
Background Cross-sectional observational studies have reported obesity and
cardiometabolic co-morbidities as important predictors of coronavirus disease 2019 (COVID …

Statin and outcomes of coronavirus disease 2019 (COVID-19): A systematic review, meta-analysis, and meta-regression

TI Hariyanto, A Kurniawan - Nutrition, Metabolism and Cardiovascular …, 2021 - Elsevier
Aims One of the comorbidities associated with severe outcome and mortality of COVID-19 is
dyslipidemia. Statin is one of the drugs which is most commonly used for the treatment of …

Statin use is associated with lower disease severity in COVID-19 infection

WYT Tan, BE Young, DC Lye, DEK Chew, R Dalan - Scientific reports, 2020 - nature.com
We aim to study the association of hyperlipidemia and statin use with COVID-19 severity. We
analysed a retrospective cohort of 717 patients admitted to a tertiary centre in Singapore for …