Background Encouraged by the goal of developing an effective treatment strategy for
prostate cancer, this study explored the mechanism involved in metformin-mediated …

Background Metformin may exert the anticancer effect on multiple types of cancers and
some potential mechanisms have been suggested. Our study was designed to determine …

Metformin has been used to treat cases of type 2 diabetes mellitus, and mounting studies
have shown that metformin can act alone or in synergy with other anticancer agents to …

BACKGROUND Metformin has been reported to inhibit the growth of different types of
cancers, including prostate cancer. We were interested to understand if the effect of …

Background To observe and explore the effect of metformin on the migration and
proliferation of bladder cancer T24 and 5637 cells in vitro. Methods Bladder cancer T24 and …

Simple Summary In this study, we found that metformin could inhibit the cell proliferation of
Oral Squamous Cell Carcinoma (OSCC) by promoting apoptosis and blocking the cell cycle …

Autophagy is a cellular mechanism by which cells degrade intracellular components in
lysosomes, maintaining cellular homeostasis. It has been hypothesized that autophagy …

Abstract Glucocorticoid (GC)-induced osteoporosis (GIOP) is the most common type of
secondary osteoporosis. Osteoblast apoptosis induced by GCs is now considered as a …

Targeting cancer cell metabolism is a new promising strategy to fight cancer. Metformin, a
widely used antidiabetic agent, and 2-deoxyglucose (2DG) drastically affect cancer cell …

Metformin is the most widely used antidiabetic drug because of its proven efficacy and
limited secondary effects. Interestingly, recent studies have reported that metformin can …