Novel host restriction factors implicated in HIV-1 replication
Human immunodeficiency virus-1 (HIV-1) is known to interact with multiple host cellular
proteins during its replication in the target cell. While many of these host cellular proteins …
proteins during its replication in the target cell. While many of these host cellular proteins …
HIV restriction factors and mechanisms of evasion
MH Malim, PD Bieniasz - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Retroviruses have long been a fertile model for discovering host–pathogen interactions and
their associated biological principles and processes. These advances have not only …
their associated biological principles and processes. These advances have not only …
Novel factors interfering with human immunodeficiency virus‐type 1 replication in vivo and in vitro
E Vicenzi, G Poli - Tissue Antigens, 2013 - Wiley Online Library
The strategy of all retroviral infections is based on establishing an equilibrium between virus
replication and proviral latency in the infected host. The human immunodeficiency virus‐type …
replication and proviral latency in the infected host. The human immunodeficiency virus‐type …
Human cellular restriction factors that target HIV-1 replication
K Strebel, J Luban, KT Jeang - BMC medicine, 2009 - Springer
Recent findings have highlighted roles played by innate cellular factors in restricting
intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein …
intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein …
A unified concept of HIV latency
O Bagasra - Expert opinion on biological therapy, 2006 - Taylor & Francis
The introduction of highly active antiretroviral therapy (HAART) combining potent drugs that
can inhibit reverse transcriptase, integrase and protease activities has changed the natural …
can inhibit reverse transcriptase, integrase and protease activities has changed the natural …
Restriction of retroviral replication by APOBEC3G/F and TRIM5α
H Huthoff, GJ Towers - Trends in microbiology, 2008 - cell.com
Pathogenic viral infections have exerted selection pressure on their hosts to evolve cellular
antiviral inhibitors referred to as restriction factors. Examples of such molecules are …
antiviral inhibitors referred to as restriction factors. Examples of such molecules are …
The restriction factors of human immunodeficiency virus
RS Harris, JF Hultquist, DT Evans - Journal of Biological Chemistry, 2012 - ASBMB
Cellular proteins called" restriction factors" can serve as powerful blockades to HIV
replication, but the virus possesses elaborate strategies to circumvent these barriers. First …
replication, but the virus possesses elaborate strategies to circumvent these barriers. First …
Inhibition of HIV-1 replication by simian restriction factors, TRIM5α and APOBEC3G
R Sakuma, JA Noser, S Ohmine, Y Ikeda - Gene therapy, 2007 - nature.com
Old World monkey TRIM5α targets incoming human immunodeficiency virus type 1 (HIV-1)
viral capsid, whereas the apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like …
viral capsid, whereas the apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like …
Generation of HIV-1 derivatives that productively infect macaque monkey lymphoid cells
K Kamada, T Igarashi, MA Martin… - Proceedings of the …, 2006 - National Acad Sciences
The narrow host range of human immunodeficiency virus type 1 (HIV-1) is caused in part by
innate cellular factors such as apolipoprotein B mRNA-editing enzyme-catalytic polypeptide …
innate cellular factors such as apolipoprotein B mRNA-editing enzyme-catalytic polypeptide …
HIV suppression by host restriction factors and viral immune evasion
Highlights•Trim5α senses HIV capsid patterns and achieves strong binding by avidity.•MxB
binds to the HIV capsid assembly and may interfere with HIV nuclear import.•HIV-1 Vif …
binds to the HIV capsid assembly and may interfere with HIV nuclear import.•HIV-1 Vif …