Hexavalent chromium induces chromosome instability in human urothelial cells
Numerous metals are well-known human bladder carcinogens. Despite the significant
occupational and public health concern of metals and bladder cancer, the carcinogenic …
occupational and public health concern of metals and bladder cancer, the carcinogenic …
Zinc chromate induces chromosome instability and DNA double strand breaks in human lung cells
H Xie, AL Holmes, JL Young, Q Qin, K Joyce… - Toxicology and applied …, 2009 - Elsevier
Hexavalent chromium Cr (VI) is a respiratory toxicant and carcinogen, with solubility playing
an important role in its carcinogenic potential. Zinc chromate, a water insoluble or …
an important role in its carcinogenic potential. Zinc chromate, a water insoluble or …
Comparative genotoxicity and cytotoxicity of four hexavalent chromium compounds in human bronchial cells
Hexavalent chromium (Cr (VI)) compounds are well-established human lung carcinogens.
Solubility plays an important role in their carcinogenicity with the particulate Cr (VI) …
Solubility plays an important role in their carcinogenicity with the particulate Cr (VI) …
Lead chromate-induced chromosome damage requires extracellular dissolution to liberate chromium ions but does not require particle internalization or intracellular …
H Xie, AL Holmes, SS Wise, N Gordon… - Chemical research in …, 2004 - ACS Publications
Hexavalent chromium [Cr (VI)] is a well-established human lung carcinogen. Water solubility
has proven to be a key factor in the carcinogenicity of Cr (VI), with the water insoluble or …
has proven to be a key factor in the carcinogenicity of Cr (VI), with the water insoluble or …
Comparison of two particulate hexavalent chromium compounds: barium chromate is more genotoxic than lead chromate in human lung cells
SS Wise, JHC Schuler, AL Holmes… - Environmental and …, 2004 - Wiley Online Library
Particulate hexavalent chromium [Cr (VI)] compounds are well‐established human lung
carcinogens. However, their carcinogenic mechanisms are poorly understood as most …
carcinogens. However, their carcinogenic mechanisms are poorly understood as most …
Particulate and soluble hexavalent chromium are cytotoxic and genotoxic to human lung epithelial cells
SS Wise, AL Holmes, JP Wise Sr - Mutation Research/Genetic Toxicology …, 2006 - Elsevier
Particulate hexavalent chromium (Cr (VI)) is a well-established human lung carcinogen. It is
currently a major public health concern, there is widespread exposure to it in occupational …
currently a major public health concern, there is widespread exposure to it in occupational …
Homologous recombination repair protects against particulate chromate-induced chromosome instability in Chinese hamster cells
MM Stackpole, SS Wise, BC Goodale… - Mutation Research …, 2007 - Elsevier
Particulate hexavalent chromium [Cr (VI)] compounds are well-established human
carcinogens. Cr (VI)-induced tumors are characterized by chromosomal instability (CIN); …
carcinogens. Cr (VI)-induced tumors are characterized by chromosomal instability (CIN); …
Chronic exposure to zinc chromate induces centrosome amplification and spindle assembly checkpoint bypass in human lung fibroblasts
AL Holmes, SS Wise, SC Pelsue… - Chemical research in …, 2010 - ACS Publications
Hexavalent chromium (Cr (VI)) compounds are known human lung carcinogens. Solubility
plays an important role in its carcinogenicity with the particulate or insoluble form being the …
plays an important role in its carcinogenicity with the particulate or insoluble form being the …
Carcinogenicity of hexavalent chromium
Abstract Hexavalent chromium (Cr (VI)), a commonly used industrial metal, is a well known
human lung carcinogen. Epidemiology and animal studies suggest that the particulate Cr …
human lung carcinogen. Epidemiology and animal studies suggest that the particulate Cr …
Chromium induces chromosomal instability, which is partly due to deregulation of BubR1 and Emi1, two APC/C inhibitors
L Hu, X Liu, Y Chervona, F Yang, M Tang… - Cell Cycle, 2011 - Taylor & Francis
Disruption of cell cycle checkpoints and interference with the normal cell cycle progression
frequently result in cell death or malignant transformation. Hexavalent chromium [Cr (VI)] is a …
frequently result in cell death or malignant transformation. Hexavalent chromium [Cr (VI)] is a …