Strategies toward Metal‐Free Carbon Monoxide Prodrugs: An Update

Q Min, X Ji - ChemMedChem, 2023 - Wiley Online Library
Carbon monoxide is an important gasotransmitter in mammals, with pleiotropic therapeutic
potential against a wide range of human diseases. However, clinical translation of CO is …

Toward carbon monoxide based therapeutics: carbon monoxide in a pill

X Ji, B Wang - Pharmaceutical Patent Analyst, 2017 - Taylor & Francis
As one of the three known gasotransmitters, carbon monoxide (CO) has demonstrated
therapeutic potential against a wide range of human diseases. However, development of CO …

Strategies toward organic carbon monoxide prodrugs

X Ji, B Wang - Accounts of Chemical Research, 2018 - ACS Publications
Conspectus Carbon monoxide is widely acknowledged as an important gasotransmitter in
the mammalian system with importance on par with that of nitric oxide. It has also been firmly …

Towards “CO in a pill”: Pharmacokinetic studies of carbon monoxide prodrugs in mice

M Wang, X Yang, Z Pan, Y Wang, LK De La Cruz… - Journal of Controlled …, 2020 - Elsevier
Carbon monoxide (CO) is a known endogenous signaling molecule with potential
therapeutic indications in treating inflammation, cancer, neuroprotection, and sickle cell …

pH-Sensitive metal-free carbon monoxide prodrugs with tunable and predictable release rates

X Ji, LKC De La Cruz, Z Pan, V Chittavong… - Chemical …, 2017 - pubs.rsc.org
Carbon monoxide prodrugs with triggered release profiles are highly desirable for targeted
CO delivery to minimize their untoward side-effects. Herein, we describe a series of pH …

Targeted delivery of carbon monoxide

LM Berreau - Carbon Monoxide in Drug Discovery: Basics …, 2022 - Wiley Online Library
Carbon monoxide (CO) is widely known for its strong binding affinity to heme proteins and
for its potential toxicity. This chapter examines the current landscape of targeted CO delivery …

A click-and-release approach to CO prodrugs

D Wang, E Viennois, K Ji, K Damera… - Chemical …, 2014 - pubs.rsc.org
Carbon monoxide belongs to the family of signaling molecules and has been shown to
possess therapeutic effects. Similar to NO, safe delivery of CO is a key issue in developing …

Organic CO prodrugs: Structure–CO‐release rate relationship studies

Z Pan, V Chittavong, W Li, J Zhang, K Ji… - … A European Journal, 2017 - Wiley Online Library
Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and
may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A …

Developing drug molecules for therapy with carbon monoxide

CC Romao, WA Blättler, JD Seixas… - Chemical Society …, 2012 - pubs.rsc.org
The use of Carbon Monoxide (CO) as a therapeutic agent has already been tested in human
clinical trials. Pre-clinically, CO gas administration proved beneficial in animal models of …

Water-Soluble carbon monoxide-releasing molecules (CORMs)

H Khan, M Faizan, SUK Niazi, Madiha… - Topics in Current …, 2023 - Springer
Carbon monoxide-releasing molecules (CORMs) are promising candidates for producing
carbon monoxide in the mammalian body for therapeutic purposes. At higher …