Immune cell-derived extracellular vesicles–functions and therapeutic applications

RE Veerman, GG Akpinar, M Eldh… - Trends in molecular …, 2019 - cell.com
Extracellular vesicles (EVs) are nano-sized vesicles with the capacity to transfer nucleic
acids, proteins, and lipids, and are released by all cells. EV is an umbrella term for …

[HTML][HTML] Immunotherapeutic potential of extracellular vesicles

B Zhang, Y Yin, RC Lai, SK Lim - Frontiers in immunology, 2014 - frontiersin.org
Extracellular vesicle or EV is a term that encompasses all classes of secreted lipid
membrane vesicles. Despite being scientific novelties, EVs are gaining importance as a …

[HTML][HTML] The function and clinical application of extracellular vesicles in innate immune regulation

X Zhou, F Xie, L Wang, L Zhang, S Zhang… - Cellular & molecular …, 2020 - nature.com
The innate immune system plays a crucial role in the host defense against viral and
microbial infection. Exosomes constitute a subset of extracellular vesicles (EVs) that can be …

[HTML][HTML] Extracellular vesicles: potential roles in regenerative medicine

OG De Jong, BWM Van Balkom… - Frontiers in …, 2014 - frontiersin.org
Extracellular vesicles (EV) consist of exosomes, which are released upon fusion of the
multivesicular body with the cell membrane, and microvesicles, which are released directly …

[HTML][HTML] Exosomes: versatile nano mediators of immune regulation

Q Li, H Wang, H Peng, T Huyan, NA Cacalano - Cancers, 2019 - mdpi.com
One of many types of extracellular vesicles (EVs), exosomes are nanovesicle structures that
are released by almost all living cells that can perform a wide range of critical biological …

Regulation of immune responses by extracellular vesicles

PD Robbins, AE Morelli - Nature Reviews Immunology, 2014 - nature.com
Extracellular vesicles, including exosomes, are small membrane vesicles derived from
multivesicular bodies or from the plasma membrane. Most, if not all, cell types release …

[HTML][HTML] Immune cells-derived exosomes function as a double-edged sword: role in disease progression and their therapeutic applications

A Hazrati, S Soudi, K Malekpour, M Mahmoudi… - Biomarker …, 2022 - Springer
Exosomes, ranging in size from 30 to 150 nm as identified initially via electron microscopy in
1946, are one of the extracellular vesicles (EVs) produced by many cells and have been the …

Extracellular vesicles in cancer immune microenvironment and cancer immunotherapy

F Xie, X Zhou, M Fang, H Li, P Su, Y Tu… - Advanced …, 2019 - Wiley Online Library
Extracellular vesicles (EVs) are secreted by almost all cells. They contain proteins, lipids,
and nucleic acids which are delivered from the parent cells to the recipient cells. Thereby …

[HTML][HTML] Immunoregulatory effects of stem cell-derived extracellular vesicles on immune cells

M Xie, W Xiong, Z She, Z Wen, AS Abdirahman… - Frontiers in …, 2020 - frontiersin.org
Recent investigations on the regulatory action of extracellular vesicles (EVs) on immune
cells in vitro and in vivo have sparked interest on the subject. As commonly known, EVs are …

Exosomes and their roles in immune regulation and cancer

DW Greening, SK Gopal, R Xu, RJ Simpson… - Seminars in cell & …, 2015 - Elsevier
Exosomes, a subset of extracellular vesicles (EVs), function as a mode of intercellular
communication and molecular transfer. Exosomes facilitate the direct extracellular transfer of …