Chemokines and chemokine receptors contribute to the migration of hepatic stellate cells
(HSCs) and Kupffer cells, two key cell types in fibrogenesis. Here, we investigate the role of …

Hepatic fibrosis develops as a response to chronic liver injury and almost exclusively occurs
in a proinflammatory environment. However, the role of inflammatory mediators in fibrogenic …

Inflammation has been shown to induce the progression of fibrosis in response to liver
injury. Among inflammatory cells, macrophages and lymphocytes play major roles in both …

Chemokines critically control the infiltration of immune cells upon liver injury, thereby
promoting hepatic inflammation and fibrosis. The chemokine receptor CCR8 can affect …

Chemokine receptors mediate migration of immune cells into the liver, thereby promoting
liver inflammation. C‐C motif chemokine receptor (CCR) 9+ macrophages are crucial in the …

Activation of hepatic stellate cells in response to chronic inflammation represents a crucial
step in the development of liver fibrosis. However, the molecules involved in the interaction …

Chronic liver injury promotes hepatic inflammation, representing a prerequisite for organ
fibrosis. We hypothesized a contribution of chemokine receptor CCR6 and its ligand …

Sustained inflammation upon chronic liver injury induces the development of liver fibrosis in
mice and men. Experimental models of liver fibrosis highlight the importance of hepatic …

Despite increasing knowledge about molecular pathways in pathogenesis of chronic liver
disease, selective therapeutic options are scarce, especially in advanced diseases …

Recent data suggest that the chemokine receptor CXCR3 is functionally involved in
fibroproliferative disorders, including liver fibrosis. Neoangiogenesis is an important …