Tumors are dynamic tissue masses, so requiring continuous exposure to the host cells,
nurturing them into pave a path for tumor growth and metastasis. CXC chemokine ligand 12 …

The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors
(GPCRs) activated through their shared ligand CXCL12 in multiple human cancers. They …

The tumor microenvironment comprises stromal and tumor cells which interact with each
other through complex cross-talks that are mediated by a variety of growth factors, cytokines …

Chemokines are a class of pro-inflammatory cytokines that can recruit and activate
chemotactic cells. C‐X‐C motif chemokine ligand 5 (CXCL5) is a member of the chemokine …

Tumor microenvironment (TME) is the local environment of tumor, composed of tumor cells
and blood vessels, extracellular matrix (ECM), immune cells, and metabolic and signaling …

The tumor microenvironment represents a dynamic and complex cellular network involving
intricate communications between the tumor and highly heterogeneous groups of cells …

Persistent infection or chronic inflammation contributes significantly to tumourigenesis and
tumour progression. CXC motif ligand 8 (CXCL8) is a chemokine that acts as an important …

Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-
protein-coupled seven-span transmembrane receptors, are major regulators of cell …

The chemokine ligand CXC motif chemokine ligand 12 (CXCL12) is a kind of small
molecules of cytokines that widely expressed in diversified tissues. Recent evidence …

Simple Summary Chemokines are small soluble proteins that control and regulate cell
trafficking within and between tissues by binding to their receptors. Among them, CXCL12 …