Pore-forming Gasdermin protein-induced pyroptosis in tumor cells promotes anti-tumor
immune response through the release of pro-inflammatory cytokines and immunogenic …

The goal of cancer immunotherapy is to clear tumor cells by activating antitumor immunity,
especially by mobilizing tumor-reactive CD8+ T cells. Pyroptosis, programmed lytic cell …

Pyroptosis is a programmed necrotic cell death mediated by pore-forming Gasdermin
(GSDM) proteins. After being unleashed from the C-terminal auto-inhibitory domains by …

To develop next-generation metal drugs with high efficiency and low toxicity for targeting
inhibition of gastric tumor growth and metastasis, we not only optimized a series of …

Pyroptosis is a proinflammatory form of cell death, mediated by membrane pore-forming
proteins called gasdermins. Gasdermin pores allow the release of the pro-inflammatory …

Effective pyroptosis induction is a promising approach to potentiate cancer immunotherapy.
However, the actual efficacy of the present pyroptosis inducers can be weakened by …

Gasdermin E (GSDME) is a member of the gasdermin protein family, which mediates
programmed cell death including apoptosis and pyroptosis. Recently, it was suggested that …

Pyroptosis is a gasdermin-mediated programmed necrosis that occurs via membrane
perforation and that can be exploited for biomedical applications in cancer therapy …

Canonically, gasdermin D (GSDMD) cleavage by caspase-1 through inflammasome
signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen …

Pyroptosis is a necrotic form of regulated cell death. Gasdermines (GSDMs) are a family of
intracellular proteins that execute pyroptosis. While GSDMs are expressed as inactive forms …