BACKGROUND The acquisition of an androgen‐independent phenotype is the most serious
issue of prostate cancer treatment. Although several experimental cell models have been …

BACKGROUND Clinically, the lethal phenotypes of human prostate cancer are
characterized by their progression to androgen‐independence and their propensity to form …

Because of the heterogeneous nature of prostate cancer, identifying the molecular
mechanisms involved during the transition from an androgen-sensitive to an androgen …

BACKGROUND There is no effective therapy currently available for androgen‐independent
(AI) prostate cancer (CaP). This is largely due to lack of information about the molecular …

Androgens regulate the proliferation of their target cells through a sequential two-step
mechanism. In the first step, androgens increase proliferation rates; following this …

Purpose The mechanism of progression of human prostate cancer (CaP) cells under
androgen ablation therapy remains unclear. To study the alternative pathways of CaP cell …

A cure for prostate cancer (CaP) will be possible only after a complete understanding of the
mechanisms causing this disease to progress from androgen dependence to androgen …

The goal of this study is to investigate the molecular mechanisms of androgen-independent
growth in prostate cancer. We have established an androgen-independent prostatic …

Lethal phenotypes of human prostate cancer are characterized by progression to androgen‐
independence and metastasis. For want of a clinically relevant animal model, mechanisms …

Androgen receptor (AR) is known to be overexpressed in castration-resistant prostate
cancer. To interrogate the functional significance of the AR level, we established two LNCaP …