Besides being one of the mechanisms responsible for ventilator-induced lung injury,
atelectasis also seems to aggravate the course of experimental pneumonia. In this study, we …

Objective Surfactant offers protection against alveolar collapse and contributes to the local
defense mechanism, but it is unclear if surfactant alterations have a role in the development …

Objective To test the hypothesis that the lung injury induced by certain mechanical
ventilation strategies is associated with changes in the pulmonary surfactant system. Design …

Variable or noisy ventilation, which includes random breath-to-breath variations in tidal
volume (Vt) and frequency, has been shown to consistently improve blood oxygenation …

We tested the hypothesis that collapsed alveoli opened by a recruitment maneuver would be
unstable or recollapse without adequate positive end-expiratory pressure (PEEP) after …

This study evaluated the effects of varying tidal volumes (VT) and positive end-expiratory
pressure (PEEP) levels on surfactant aggregate conversion and lung function in an animal …

Reexpansion of collapsed lung creates intrapulmonary shear forces. In an earlier study we
showed that application of a negative end-expiratory airway pressure (NEEP) to normal …

Objective To evaluate the effect of VT reduction and alveolar recruitment on systemic and
contralateral dissemination of bacteria and inflammation during right-side pneumonia …

We investigated the effect of inoculum size on early pulmonary bacterial clearance of
Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae, and …

Rationale: Although surfactant replacement therapy is an established treatment in infant
respiratory distress syndrome, the optimum strategy for ventilatory management before …