Objective—Impaired endothelial cell (EC) autophagy compromises shear stress–induced
nitric oxide (NO) generation. We determined the responsible mechanism. Approach and …

Autophagy is a lysosomal catabolic process by which cells degrade or recycle their contents
to maintain cellular homeostasis, adapt to stress, and respond to disease. Impairment of …

Aim The importance of endothelial cell (EC) autophagy to vascular homeostasis in the
context of health and disease is evolving. Earlier, we reported that intact EC autophagy is …

Continuous laminar shear stress increases the process of autophagy, activates endothelial
nitric oxide (NO) synthase phosphorylation at serine 1177 (p-eNOSS1177), and generates …

Disturbed cell autophagy is found in various cardiovascular disease conditions.
Biomechanical stimuli induced by laminar blood flow have important protective actions …

Aim: Temporal and spatial variations in shear stress are intimately linked with vascular
metabolic effects. Autophagy is tightly regulated in intracellular bulk degradation/recycling …

Vascular endothelial cell function responds to steady laminar shear stress; however, the
underlying mechanisms are not fully elucidated. In the present study, we examined the effect …

Uncoupled endothelial nitric oxide synthase (eNOS) produces O 2 radical dot− instead of
nitric oxide (NO). Earlier, we reported rapamycin, an autophagy inducer and inhibitor of …

Autophagy is a cellular self-digestion process activated in response to stresses such as
energy deprivation and oxidative stress. However, the mechanisms by which energy …

Blood flowing in arteries generates shear forces at the surface of the vascular endothelium
that control its anti-atherogenic properties. However, due to the architecture of the vascular …