We have investigated the effect of serum on nanometric structure, size, surface potential,
DNA-binding capacity, and transfection efficiency of DDAB-DOPE/DNA and DC-Chol …

Cationic liposomes are used to deliver genes into cells. Here we describe some poorly
understood basic features of DNA–lipid complexes (lipoplexes), especially the electrostatics …

Reported here is the correlation between the transfection efficiency of cationic
liposome/DNA complexes (lipoplexes) and the structural evolution that they undergo when …

To evaluate the role of lipid charge density in the serum stability of DOTAP-Chol/DNA
complexes (lipoplexes), lipid–DNA interactions, extent of aggregation, supercoil content …

Motivated by its important role in gene delivery, we have studied the effect of cholesterol and
analogs on the transfection efficiency (TE) of lamellar cationic liposome− DNA (CL− DNA) …

Cationic liposome–DNA complexes (lipoplexes) have emerged as leading nonviral gene
carriers in worldwide gene therapy clinical trials. Arriving at therapeutic dosages requires …

The supramolecular structural nature of some cationic liposomes–DNA complexes, currently
used as vehicles in non-viral gene delivery, has been elucidated by recent X-ray diffraction …

Lipoplexes are complexes formed between cationic liposomes (L+) and polyanionic nucleic
acids (P−). They are commonly used in vitro and in vivo as a nucleic acid delivery system …

Clinical applications of gene therapy mainly depend on the development of efficient gene
transfer vectors. Large DNA molecules can only be transfected into cells by using synthetic …

We have investigated the morphology and transfection activity of cationic liposome-DNA
complexes (CLDC) under conditions relevant to both in vivo and in vitro studies. Moreover …