Amotivation is associated with smaller ventral striatum volumes in older patients with schizophrenia
F Caravaggio, G Fervaha, Y Iwata… - … journal of geriatric …, 2018 - Wiley Online Library
Objective Motivational deficits are prevalent in patients with schizophrenia, persist despite
antipsychotic treatment, and predict long‐term outcomes. Evidence suggests that patients …
antipsychotic treatment, and predict long‐term outcomes. Evidence suggests that patients …
Apathy is not associated with reduced ventral striatal volume in patients with schizophrenia
Background A growing body of neuroimaging research has revealed a relationship between
blunted activation of the ventral striatum (VS) and apathy in schizophrenia. In contrast, the …
blunted activation of the ventral striatum (VS) and apathy in schizophrenia. In contrast, the …
Striatal function in relation to negative symptoms in schizophrenia
BackgroundPrevious studies have suggested that motivational aspects of executive
functioning, which may be disrupted in schizophrenia patients with negative symptoms, are …
functioning, which may be disrupted in schizophrenia patients with negative symptoms, are …
Amotivation in schizophrenia: integrated assessment with behavioral, clinical, and imaging measures
DH Wolf, TD Satterthwaite, JJ Kantrowitz… - Schizophrenia …, 2014 - academic.oup.com
Motivational deficits play a central role in disability caused by schizophrenia and constitute a
major unmet therapeutic need. Negative symptoms have previously been linked to …
major unmet therapeutic need. Negative symptoms have previously been linked to …
Striatal Response to Reward Anticipation as a Biomarker for Schizophrenia and Negative Symptoms: Effects, Test-Retest Reliability, and Stability Across Sites
F Carruzzo, M Kaliuzhna, N Kuenzi… - Schizophrenia …, 2024 - academic.oup.com
Background Ventral striatal hypoactivation during reward anticipation has consistently been
observed in patients with schizophrenia. In addition, that hypoactivation has been shown to …
observed in patients with schizophrenia. In addition, that hypoactivation has been shown to …
Relationship of ventral striatum activation during effort discounting to clinical amotivation severity in schizophrenia
Motivational deficits play a central role in disability due to negative symptoms of
schizophrenia (SZ), but limited pathophysiological understanding impedes critically needed …
schizophrenia (SZ), but limited pathophysiological understanding impedes critically needed …
Dysfunction of ventral striatal reward prediction in schizophrenia
Background: Negative symptoms may be associated with dysfunction of the brain reward
system in schizophrenia. We used functional magnetic resonance imaging (fMRI) to assess …
system in schizophrenia. We used functional magnetic resonance imaging (fMRI) to assess …
Cognition and dopamine D2 receptor availability in the striatum in older patients with schizophrenia
Objectives To assess the impact of reducing the dose of antipsychotics on cognition and
dopaminergic D 2 receptor availability in the whole striatum, and identify their relationship in …
dopaminergic D 2 receptor availability in the whole striatum, and identify their relationship in …
Increased intrinsic brain activity in the striatum reflects symptom dimensions in schizophrenia
Striatal dysfunction is thought to be a fundamental element in schizophrenia. Striatal
dopamine dysfunction impacts on reward processing and learning and is present even at …
dopamine dysfunction impacts on reward processing and learning and is present even at …
Functional connectivity of the ventral tegmental area and avolition in subjects with schizophrenia: a resting state functional MRI study
Avolition, a deficit in goal-directed behavior, is a key aspect of negative symptoms. It is
highly prevalent in schizophrenia and is associated to poor functional outcome and to …
highly prevalent in schizophrenia and is associated to poor functional outcome and to …