Hormone receptor positive (HR+) breast cancer represent 70% of all breast tumours. Its
oncogenesis is multiple step process thought to be driven by the presence of two …

We have used a proteomics subcellular spatial razor approach to look at changes in total
protein abundance and in protein distribution between the nucleus and cytoplasm following …

At the molecular level, living cells are enormously complicated complex adaptive systems in
which intertwined genomic, transcriptomic, proteomic and metabolic networks all play a …

PURPOSE The discovery of the oestrogen and her-2 receptor proteins paved the way for the
subsequent development of adjunctive therapeutic options for the treatment of breast …

Estrogens exert their function through genomic and non-genomic pathways mediated mainly
by estrogen receptors. Estrogen signalling is highly complex and once activated initiates …

Identification of the proteins that are associated with estrogen receptor (ER) status is a first
step towards better understanding of the hormone-dependent nature of breast …

The role of estrogen receptor signalling is pivotal in breast cancer initiation and
development. Numerous studies have undertaken the identification of estrogen regulated …

Cancer is characterized by a deregulation of the cell cycle resulting in abnormal proliferation
of cells that can bypass tightly regulated molecular checkpoints. Breast cancer is the most …

Proteome comparison of cell lines derived from cancer and normal breast epithelium
provide opportunities to identify differentially expressed proteins and pathways associated …

This thesis analyzes the dynamic complexity involved in the subcellular distribution of the
proteins for the malignant breast epithelial MCF-7 cell line, using mass spectrometry based …