Non-targeted metallomics through synchrotron radiation X-ray fluorescence with machine learning for cancer screening using blood samples

L He, Y Lu, C Li, H Xie, J Zhao, Y Wang, L Wang… - Talanta, 2022 - Elsevier
Cancer is the leading cause of death in many countries. The development of new methods
for early screening of cancers is highly desired. Targeted metallomics has been successfully …

Trace metal biomarker based Cancer diagnostics in body tissue by energy dispersive X-ray fluorescence and scattering spectrometry

EK Sichangi, HK Angeyo… - Spectrochimica Acta Part …, 2019 - Elsevier
Direct diagnosis and characterization of cancer in tissue via trace biometals analyzed by
energy dispersive X-ray fluorescence (EDXRF) spectrometry is challenging, as it requires …

Chemometrics aided energy dispersive X-ray fluorescence and scattering for diagnostic modeling of trace biometals as cancer biomarkers

JJ Okonda, HK Angeyo, A Dehayem-Kamadjeu… - Applied Radiation and …, 2022 - Elsevier
Direct analysis of biometals in biomedical samples by energy dispersive X-ray fluorescence
(EDXRF) for disease diagnostics has hardly been fully explored due to dark matrix analytical …

Hybridized robust chemometrics approach for direct rapid determination of trace biometals in tissue utilizing energy dispersive X-ray fluorescence and scattering …

EK Sichangi, HK Angeyo… - Radiation Physics and …, 2018 - Elsevier
Direct rapid energy dispersive X-ray fluorescence and scattering (EDXRFS) analysis of trace
biometals in soft body tissues is important because it has an immense potential for …

The use of X-ray absorption and synchrotron based micro-X-ray fluorescence spectroscopy to investigate anti-cancer metal compounds in vivo and in vitro

AA Hummer, A Rompel - Metallomics, 2013 - academic.oup.com
X-ray absorption spectroscopy (XAS) and micro-synchrotron based X-ray fluorescence
(micro-SXRF) are element specific spectroscopic techniques and have been proven to be …

Analysis of human tissues using Energy Dispersive X Ray Fluorescence–Dark matrix determination for the application to cancer research

A Ensina, PM Carvalho, J Machado… - Journal of Trace …, 2021 - Elsevier
Background X ray Fluorescence has been essayed as a suitable technique for the elemental
quantification of trace element in human tissues, namely comparison of normal and …

Detecting trace levels of heavy metals in pharmaceutical raw materials with wavelength-dispersive X-ray fluorescence spectroscopy and curve-fitting regression

P Kikongi, C Fauteux-Lefebvre, J Salvas… - Spectrochimica Acta Part …, 2018 - Elsevier
This paper proposes the application of curve-fitting regression (CFR) to wavelength-
dispersive X-ray fluorescence as a novel way to quantify traces of heavy metals in …

[HTML][HTML] Evaluation of different analytical approaches using total reflection X-ray fluorescence systems for multielemental analysis of human tissues with different …

PM Carvalho, E Marguí, A Kubala-Kukuś… - … Acta Part B: Atomic …, 2022 - Elsevier
Elemental content plays an important role in biological processes, and so, the
multielemental analysis of human tissue samples is required in biomedical research. Still …

Accuracy improvement in XRF analysis for the quantification of elements ranging from tenths to thousands μg g− 1 in human tissues using different matrix reference …

J Machado, PM Carvalho, A Félix, D Doutel… - Journal of Analytical …, 2020 - pubs.rsc.org
In this work, we aim at achieving the most accurate quantitative determination of elements in
human tissues by means of X-ray Fluorescence spectrometry using the external calibration …

Investigation of element distribution and homogeneity of TXRF samples using SR-micro-XRF to validate the use of an internal standard and improve external standard …

C Horntrich, S Smolek, A Maderitsch, R Simon… - Analytical and …, 2011 - Springer
Total reflection X-ray fluorescence analysis (TXRF) offers a nondestructive qualitative and
quantitative analysis of trace elements. Due to its outstanding properties TXRF is widely …