[HTML][HTML] A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors
N Conlon, AM Schultheis, S Piscuoglio, A Silva… - Modern Pathology, 2015 - Elsevier
Sertoli–Leydig cell tumors are characterized by the presence of somatic DICER1 hotspot
mutations. In this study, we sought to define the association between DICER1 hotspot …
mutations. In this study, we sought to define the association between DICER1 hotspot …
DICER1 mutations are consistently present in moderately and poorly differentiated Sertoli-Leydig cell tumors
L de Kock, T Terzic, WG McCluggage… - The American journal …, 2017 - journals.lww.com
Abstract Ovarian Sertoli-Leydig cell tumors (SLCTs) are uncommon sex cord-stromal tumors
associated with both germ-line and somatic DICER1 mutations, the frequency of which has …
associated with both germ-line and somatic DICER1 mutations, the frequency of which has …
Well-differentiated Sertoli-Leydig cell tumors (SLCTs) are not associated with DICER1 pathogenic variants and represent a different tumor type to moderately and …
WG McCluggage, B Rivera, AS Chong… - The American Journal …, 2023 - journals.lww.com
Abstract Sertoli-Leydig cell tumors (SLCTs) are uncommon ovarian sex cord-stromal
neoplasms which are currently classified into well, moderately, and poorly differentiated and …
neoplasms which are currently classified into well, moderately, and poorly differentiated and …
Ovarian sex cord-stromal tumors in patients with probable or confirmed germline DICER1 mutations
EE Oost, A Charles, CS Choong… - International Journal …, 2015 - journals.lww.com
The DICER1 gene encodes an endoribonuclease involved in the production of mature
microRNAs which regulates gene expression through several mechanisms. Recent studies …
microRNAs which regulates gene expression through several mechanisms. Recent studies …
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry
Background Ovarian sex cord-stromal tumors (OSCST) include juvenile granulosa cell
tumors (JGCT), Sertoli-Leydig cell tumor (SLCT) and gynandroblastoma (GAB) among …
tumors (JGCT), Sertoli-Leydig cell tumor (SLCT) and gynandroblastoma (GAB) among …
DICER1 and FOXL2 mutation status correlates with clinicopathologic features in ovarian Sertoli-Leydig cell tumors
AN Karnezis, Y Wang, J Keul… - The American journal …, 2019 - journals.lww.com
Abstract Sertoli-Leydig cell tumors (SLCTs) are rare ovarian sex cord-stromal neoplasms.
The only known recurrent genetic abnormality is DICER1 mutation, with rare mutations …
The only known recurrent genetic abnormality is DICER1 mutation, with rare mutations …
Spectrum of DICER1 Germline Pathogenic Variants in Ovarian Sertoli–Leydig Cell Tumor
E De Paolis, RM Paragliola, P Concolino - Journal of Clinical Medicine, 2021 - mdpi.com
Sertoli–Leydig Cell Tumors (SLCTs) are rare ovarian sex cord-stromal neoplasms, which
predominantly affect adolescents and young female adults. The SLCTs clinical diagnosis …
predominantly affect adolescents and young female adults. The SLCTs clinical diagnosis …
DICER1 hotspot mutations in ovarian Sertoli-Leydig cell tumors: a potential association with androgenic effects
N Kato, T Kusumi, A Kamataki, R Tsunoda, M Fukase… - Human pathology, 2017 - Elsevier
Summary Sertoli-Leydig cell tumors (SLCTs) are representative of androgenic ovarian
tumors, and they show diverse histologic differentiation, including heterologous …
tumors, and they show diverse histologic differentiation, including heterologous …
Gynecologic manifestations of the DICER1 syndrome
CJR Stewart, A Charles, WD Foulkes - Surgical pathology clinics, 2016 - Elsevier
Patients with germline DICER1 mutations are at increased risk of developing a wide range
of tumors, most of which are relatively rare in the general population. In the gynecologic …
of tumors, most of which are relatively rare in the general population. In the gynecologic …
DICER1 and FOXL2 mutations in ovarian sex cord–stromal tumours: a GINECO Group study
T Goulvent, I Ray‐Coquard, S Borel, V Haddad… - …, 2016 - Wiley Online Library
Aims FOXL 2 mutation has been consistently identified in adult granulosa cell tumours (A‐
GCT s). DICER 1 mutations have been described predominantly in Sertoli–Leydig cell …
GCT s). DICER 1 mutations have been described predominantly in Sertoli–Leydig cell …