The p53-inducible protein TIGAR (Tp53-induced Glycolysis and Apoptosis Regulator)
functions as a fructose-2, 6-bisphosphatase (Fru-2, 6-BPase), and through promotion of the …

The p53‐inducible TIGAR protein functions as a fructose‐2, 6‐bisphosphatase, promoting
the pentose phosphate pathway and helping to lower intracellular reactive oxygen species …

The p53 tumor-suppressor protein prevents cancer development through various
mechanisms, including the induction of cell-cycle arrest, apoptosis, and the maintenance of …

Altered metabolism in tumor cells is increasingly recognized as a core component of the
neoplastic phenotype. Because p53 has emerged as a master metabolic regulator, we …

Cancers cells shift their metabolism towards glycolysis in order to help them support the
biosynthetic demands necessary to sustain cell proliferation and growth, adapt to stress and …

Activation of the p53 tumor suppressor by cellular stress leads to variable responses ranging
from growth inhibition to apoptosis. TIGAR is a novel p53-inducible gene that inhibits …

TIGAR (TP53-induced glycolysis and apoptosis regulator) is the downstream target gene of
p53, contains a functional sequence similar to 6-phosphofructose kinase/fructose-2, 6 …

TP53-induced glycolysis and apoptosis regulator (TIGAR) is a p53 target protein that plays
critical roles in glycolysis and redox balance. Accumulating evidence shows that TIGAR is …

The p53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis, resulting in
higher intracellular NADPH, lower reactive oxygen species (ROS) and autophagy activity. In …

Bioenergetic homeostasis is altered in heart failure and may play an important role in
pathogenesis. p53 has been implicated in heart failure, and although its role in regulating …