Heart disease is the leading cause of death worldwide and imposes a significant burden on
healthcare systems globally. A major hurdle to the development of more effective …

Modeling of human organs has long been a task for scientists in order to lower the costs of
therapeutic development and understand the pathological onset of human disease. For …

Human heart (patho) physiology is now widely studied using human pluripotent stem cells,
but the immaturity of derivative cardiomyocytes has largely limited disease modeling to …

The development of organs-on-chip (OoC) has revolutionized in vitro cell-culture
experiments by allowing a better mimicry of human physiology and pathophysiology that has …

Drug discovery and development continues to be a challenge to the pharmaceutical industry
despite great advances in cell and molecular biology that allow for the design of better …

Organ-on-a-chip systems have the potential to revolutionize drug screening and disease
modeling through the use of human stem cell-derived cardiomyocytes. The predictive power …

To reduce the required capital and time investment in the development of new
pharmaceutical agents, there is an urgent need for preclinical drug testing models that are …

Drug discovery and development are hampered by high failure rates attributed to the
reliance on non-human animal models employed during safety and efficacy testing. A …

The core of the drug research and screening processes is predicting the effect of drugs prior
to human clinical trials. Due to the 2D cell culture and animal models' poor predictability, the …

The heart is one of the most vital organs in the human body, which actively pumps the blood
through the vascular network to supply nutrients to as well as to extract wastes from all other …