Various studies have reported insufficient beta-lactam concentrations in critically ill patients.
The optimal dosing strategy for beta-lactams in critically ill patients, particularly in septic …

Background Optimal anti-bacterial activity of meropenem requires maintenance of its plasma
concentration (Cp) above the minimum inhibitory concentration (MIC) of the pathogen for at …

Background Due to high pharmacokinetic variability, standard doses of meropenem are
frequently inadequate in septic patients. Therapeutic drug monitoring of meropenem is not …

Background: The proper dosage of antibiotics is a key element in the effective treatment of
infection, especially in critically ill patients. This study aimed to evaluate the efficacy of …

Introduction The purpose of this study was to explore factors influencing meropenem
pharmacokinetics (PKs) in critically ill patients by developing a population PK model and to …

The number of pharmacokinetic (PK) models of meropenem is increasing. However, the
daily role of these PK models in the clinic remains unclear, especially for critically ill patients …

Effective antibiotic dosing is vital for therapeutic success in critically ill patients. This work
aimed to develop an algorithm to identify appropriate meropenem dosing in critically ill …

Objectives To compare the plasma and subcutaneous tissue concentration–time profiles of
meropenem administered by intermittent bolus dosing or continuous infusion to critically ill …

Background Optimal antibiotic exposure is a vital but challenging prerequisite for achieving
clinical success in ICU patients. Objectives To develop and externally validate a population …

Population pharmacokinetic analyses can be applied to predict optimized dosages for
individual patients. The aim of this study was to compare the prediction performance of the …