Synaptic vesicle docking, priming, and fusion at active zones are orchestrated by a complex
molecular machinery. We employed hippocampal organotypic slice cultures from mice …

In a nerve terminal, synaptic vesicle docking and release are restricted to an active zone.
The active zone is a protein scaffold that is attached to the presynaptic plasma membrane …

Soluble N‐ethylmaleimide‐sensitive factor attachment protein receptor (SNARE) complexes
execute synaptic vesicle (SV) fusion. Vesicle fusion is preceded by an obligatory Munc13 …

This review summarizes current knowledge of synaptic proteins that are central to synaptic
vesicle fusion in presynaptic active zones, including SNAREs (s oluble N-ethylmaleimide …

The core of the neurotransmitter release machinery is formed by SNARE complexes, which
bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1 …

Munc18-1 and soluble NSF attachment protein receptors (SNAREs) are critical for synaptic
vesicle fusion. Munc18-1 binds to the SNARE syntaxin-1 folded into a closed conformation …

Here, we introduce the full functional reconstitution of genetically validated core protein
machinery (SNAREs, Munc13, Munc18, Synaptotagmin, and Complexin) for synaptic vesicle …

The release of neurotransmitter from synaptic vesicles represents the final event by which
presynapses send their chemical signal to the receiving postsynapses. Prior to fusion …

Synaptic neurotransmitter release is restricted to active zones, where the processes of
synaptic vesicle tethering, priming to fusion competence, and Ca 2+-triggered fusion are …

Synaptic vesicles undergo a maturation step, termed priming, in which they become
competent to fuse with the plasma membrane. To morphologically define the site of vesicle …