Pseudomonas aeruginosa is an opportunistic human pathogen, particularly noted for
causing infections in the lungs of people with cystic fibrosis (CF). Previous studies have …

Pseudomonas aeruginosa is one of the major causes of morbidity and mortality of cystic
fibrosis patients. During the infection, the bacteria colonize the nutritional rich lung mucus …

One of the hallmarks of Pseudomonas aeruginosa infection in cystic fibrosis (CF) patients is
very-high-cell-density (HCD) replication in the lung, allowing this bacterium to induce …

Pseudomonas aeruginosa is the dominant pathogen infecting the airways of cystic fibrosis
(CF) patients. During the intermittent colonization phase, P. aeruginosa resembles …

Pseudomonas aeruginosa forms chronic infections in the lungs of cystic fibrosis (CF)
patients, and is the leading cause of morbidity and mortality in patients with CF …

Life-long bacterial infections in cystic fibrosis (CF) airways constitute an excellent model
both for persistent infections and for microbial adaptive evolution in complex dynamic …

System-level modeling is beginning to be used to decipher high throughput data in the
context of disease. In this study, we present an integration of expression microarray data …

Previous studies have demonstrated substantial genetic diversification of Pseudomonas
aeruginosa across sub-compartments in cystic fibrosis (CF) lungs. Here, we isolate P …

The sputum (mucus) layer of the cystic fibrosis (CF) lung is a complex substrate that provides
Pseudomonas aeruginosa with carbon and energy to support high-density growth during …

The opportunistic human pathogen Pseudomonas aeruginosa causes persistent airway
infections in patients with cystic fibrosis (CF). To establish these chronic infections, P …